Association between uric acid and aortic aneurysms: A two-sample Mendelian randomization study.

IF 3.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2025-12-01 Epub Date: 2025-08-13 DOI:10.1080/10641963.2025.2539180

Tuo Xu, Yongkang Wu, Changwei Zheng, Weijie Chen, Zhi Zhang

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引用次数: 0

Abstract

Objective: Based on Mendelian randomization (MR) methods, this study aims to explore causal associations of uric acid (UA) levels with aortic aneurysms (AAs).

Methods: In this MR study, data on UA levels and gout were extracted from genome-wide association study (GWAS) meta-analysis conducted by UK Biobank (UKB) for European population and the Biobank Japan Project (BBJ) for Asian population. Summary statistics of AAs were obtained from different databases. Inverse variance weighted (IVW), weighted-mode, weighted median, MR-Egger, and MR-PRESSO methods were used to examine the potential causal association of UA with AAs.

Results: The IVW estimates indicated that elevated UA level was associated with higher AAA risk among the European population (OR = 1.315, 95%CI: 1.024-1.689). In the Asian population, the UA level was positively linked to the odds of AA (OR = 1.393, 95%CI: 1.061-1.829). In addition, sensitivity analyses through MR leave-one-out and single SNP effect methods showed that these results were relatively robust.

Conclusions: UA may be a potential risk factor for AAs, indicating that clinicians should focus on serum UA levels among populations with high-risk of AAs. Studies to reveal the true relationship between them and clarify the underlying mechanism are still needed in the future.

查看原文本刊更多论文

尿酸与主动脉瘤的关系：一项双样本孟德尔随机化研究。

目的：基于孟德尔随机化（MR）方法，本研究旨在探讨尿酸（UA）水平与主动脉瘤（AAs）的因果关系。方法：在这项MR研究中，UA水平和痛风的数据来自英国生物银行（UKB）对欧洲人群和日本生物银行项目（BBJ）对亚洲人群进行的全基因组关联研究（GWAS）荟萃分析。从不同的数据库中获得AAs的汇总统计。使用逆方差加权（IVW）、加权模式、加权中位数、MR-Egger和MR-PRESSO方法来检查UA与aa之间的潜在因果关系。结果：IVW估计表明，在欧洲人群中，UA水平升高与较高的AAA风险相关（OR = 1.315, 95%CI: 1.024-1.689）。在亚洲人群中，UA水平与AA的几率呈正相关（OR = 1.393, 95%CI: 1.061-1.829）。此外，通过MR leave- out和单SNP效应方法进行的敏感性分析表明，这些结果相对稳健。结论：UA可能是AAs的潜在危险因素，提示临床医生应关注AAs高危人群的血清UA水平。未来仍需进一步研究以揭示两者之间的真实关系并阐明其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.