Ischemia/Reperfusion Injury and Outcomes in Liver Transplantation Assessed by Omics Technologies: Where Do We Stand?

IF 5 2区医学 Q1 IMMUNOLOGY

Transplantation Pub Date : 2025-08-13 DOI:10.1097/TP.0000000000005466

Pablo J Giraudi, Gabriele Codotto, Umberto Baccarani, Francisco Baralle, Gabriel Gondolesi, Danilo Licastro, Claudio Tiribelli

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引用次数: 0

Abstract

Liver transplantation faces several biological challenges, including those related to ischemia/reperfusion injury, graft rejection or tolerance, and disease recurrence. These processes significantly impact posttransplant outcomes and highlight the need for a deeper understanding to improve patient care. The progress of omics sciences has been remarkable over the past decades, and omics techniques are widely used in clinical investigations. In this review, we have explored and briefly described investigations using omics technologies (epigenomics, transcriptomics, and proteomics) to better understand the processes affecting liver transplantation. Additionally, we have highlighted recent studies that use cutting-edge omics technologies, including single-cell RNA sequencing, spatial transcriptomics, and multiplex proteomics, often integrated into multiomics approaches, which enable a more detailed and holistic analysis of the produced data, paving the way for the discovery of precise biomarkers for liver transplant monitoring and the development of novel therapies to prevent allograft rejection.

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用组学技术评估肝移植的缺血/再灌注损伤和预后：我们站在哪里？

肝移植面临一些生物学挑战，包括与缺血/再灌注损伤、移植物排斥或耐受以及疾病复发有关的挑战。这些过程显著影响移植后的结果，并强调需要更深入地了解以改善患者护理。近几十年来，组学研究取得了长足的进步，组学技术在临床研究中得到了广泛的应用。在这篇综述中，我们探索并简要描述了使用组学技术（表观基因组学、转录组学和蛋白质组学）来更好地理解影响肝移植的过程的研究。此外，我们还重点介绍了最近使用尖端组学技术的研究，包括单细胞RNA测序、空间转录组学和多重蛋白质组学，这些技术通常集成到多组学方法中，可以对产生的数据进行更详细和全面的分析，为发现用于肝移植监测的精确生物标志物和开发防止同种异体移植排斥反应的新疗法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.