Clinical characteristics, treatment and prognosis of pembrolizumab induced myocarditis.

IF 2.7 3区 医学 Q2 ONCOLOGY
Zhaoquan Wu, Wei Sun, Chunjiang Wang
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引用次数: 0

Abstract

To explore the regularity and clinical characteristics of pembrolizumab induced myocarditis, and to provide a reference for the diagnosis and treatment of myocarditis. Clinical reports of pembrolizumab induced myocarditis were collected by searching the database as of May 31, 2025. Clinical data were extracted and analyzed statistically. A total of 97 patients were enrolled in the study, with a median age of 70 years (range 25, 89), of which 53(54.6%) were male. The median time for diagnosis of myocarditis was 25 days (range 3, 4050). The common clinical symptoms were dyspnoea (23.7%), shortness of breath (16.5%), and thoracic pain (13.4%). Myositis and/or myasthenia gravis occurred in 43.3% of the patients. These patients with myocarditis may be accompanied by abnormalities in myocardial biomarkers, electrocardiograms, cardiac magnetic resonance and echocardiograms. After the patients discontinued pembrolizumab and received steroid-based immunotherapy, 72.2% of the patients recovered and 26.8% of the patients died. Myocarditis is a rare and fatal immune-related adverse event of pembrolizumab. Cardiac biomarkers, electrocardiograms and echocardiograms should be monitored during the use of Pembrolizumab. Cardiac magnetic resonance or myocardial biopsy can be used to further confirm myocarditis.

派姆单抗致心肌炎的临床特点、治疗及预后。
探讨派姆单抗诱发心肌炎的规律及临床特点,为心肌炎的诊断和治疗提供参考。通过检索数据库收集截至2025年5月31日的派姆单抗诱导心肌炎的临床报告。提取临床资料并进行统计学分析。研究共纳入97例患者,中位年龄70岁(25 ~ 89岁),其中53例(54.6%)为男性。诊断心肌炎的中位时间为25天(范围34050)。常见临床症状为呼吸困难(23.7%)、呼吸短促(16.5%)、胸痛(13.4%)。43.3%的患者出现肌炎和/或重症肌无力。这些心肌炎患者可能伴有心肌生物标志物、心电图、心脏磁共振和超声心动图的异常。患者停用派姆单抗并接受类固醇免疫治疗后,72.2%的患者康复,26.8%的患者死亡。心肌炎是派姆单抗罕见且致命的免疫相关不良事件。在使用派姆单抗期间,应监测心脏生物标志物、心电图和超声心动图。心脏磁共振或心肌活检可进一步证实心肌炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.60
自引率
0.00%
发文量
121
审稿时长
1 months
期刊介绍: The development of new anticancer agents is one of the most rapidly changing aspects of cancer research. Investigational New Drugs provides a forum for the rapid dissemination of information on new anticancer agents. The papers published are of interest to the medical chemist, toxicologist, pharmacist, pharmacologist, biostatistician and clinical oncologist. Investigational New Drugs provides the fastest possible publication of new discoveries and results for the whole community of scientists developing anticancer agents.
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