Pretransplant screening and lower incidence of breast and prostate cancers among organ transplant recipients in the United States.

IF 4.1 Q2 ONCOLOGY
Shyfuddin Ahmed, Michael J Silverberg, Eric A Engels
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引用次数: 0

Abstract

Solid organ transplant recipients (SOTRs) in the United States have lower risks for breast and prostate cancers than the general population. To explore whether pretransplant screening explains this observation, we conducted a case-control study of US adults aged 65 years or older using the SEER-Medicare database (2000-2019). We included 252 279 breast cancer cases, 3 855 275 female controls, 316 981 prostate cancer cases, and 2 361 846 male controls. We used Medicare claims to identify solid organ transplant procedures and screening with mammography or prostate-specific antigen testing before case/control selection. SOTRs exhibited reduced risks for breast cancer (adjusted odds ratio = 0.60, 95% CI = 0.45 to 0.80) and prostate cancer (0.84, 95% CI = 0.71 to 1.00). These inverse associations were significant among screened individuals, although a borderline association for breast cancer was suggested in unscreened women. Pretransplant cancer screening probably largely explains the reduced risks of breast and prostate cancer among US SOTRs, but there may also be other protective factors.

美国器官移植受者的移植前筛查与乳腺癌和前列腺癌发病率降低
在美国,实体器官移植接受者(SOTRs)患乳腺癌和前列腺癌的风险低于普通人群。为了探讨移植前筛查是否解释了这一观察结果,我们使用SEER-Medicare数据库(2000-2019)对65岁及以上的美国成年人进行了一项病例对照研究。我们纳入了252,279例乳腺癌病例、3,855,275例女性对照、316,981例前列腺癌病例和2,361,846例男性对照。我们使用医疗保险索赔来确定实体器官移植程序,并在病例/对照选择之前用乳房x光检查或前列腺特异性抗原检测进行筛查。SOTRs患乳腺癌(校正优势比0.60,95%CI 0.45-0.80)和前列腺癌(校正优势比0.84,95%CI 0.71-1.00)的风险降低。这些负相关在接受筛查的个体中是显著的,尽管在未接受筛查的女性中存在与乳腺癌的边缘关联。移植前癌症筛查可能在很大程度上解释了美国sotr患者患乳腺癌和前列腺癌风险降低的原因,但也可能存在其他保护因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JNCI Cancer Spectrum
JNCI Cancer Spectrum Medicine-Oncology
CiteScore
7.70
自引率
0.00%
发文量
80
审稿时长
18 weeks
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