Recurrences of anaphylaxis: trends and risk factors.

IF 2.6 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-11 DOI:10.1097/ACI.0000000000001100

Pham Thao Van Luong, Pascal Demoly, Luciana Kase Tanno

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引用次数: 0

Abstract

Purpose of review: Recurrences of anaphylaxis is a concern due to its unpredictability and long-term burden to patients and healthcare systems. This review examines recurrence rates, associated risk factors, and gaps in current knowledge to guide improved clinical management.

Recent findings: From 1240 initial records, 11 studies fulfilled the inclusion criteria of our systematic review. Recurrences of anaphylaxis rates range from 2.6 to 17.6% of patients after a first episode of anaphylaxis, with a rising trend over time. Personal history of food allergy is the most consistent associated risk factor, followed by the presence of atopic comorbidities such as asthma and atopic dermatitis. Other potential factors include socioeconomic deprivation, and seasonal variations. There is lack of evidence on contributing factors to volve to more severe episodes and on how etiology may change between episodes.

Summary: Recurrences of anaphylaxis is multifactorial, with personal history of food allergy and allergic comorbidities as primary risk factors. Inconsistencies across studies underscore the need for standardized research. Limited data on severity and etiology progression highlight areas for future investigation to improve long-term outcomes.

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过敏反应的复发：趋势和危险因素。

回顾目的：过敏反应的复发是一个值得关注的问题，因为它的不可预测性和对患者和医疗保健系统的长期负担。这篇综述检查了复发率，相关的危险因素，以及当前知识的差距，以指导改进的临床管理。最新发现：从1240项初始记录中，有11项研究符合我们系统评价的纳入标准。首次过敏反应发作后，患者的过敏反应复发率为2.6 ~ 17.6%，随时间的推移呈上升趋势。个人食物过敏史是最一致的相关风险因素，其次是特应性合并症，如哮喘和特应性皮炎。其他潜在因素包括社会经济剥夺和季节变化。缺乏证据表明导致更严重的发作的因素以及发作之间的病因如何变化。总结：过敏反应的复发是多因素的，个人食物过敏史和过敏合并症是主要危险因素。研究之间的不一致性强调了标准化研究的必要性。关于严重程度和病因进展的有限数据强调了未来研究以改善长期预后的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.