{"title":"CD105 as a Marker of Angiogenesis in Oral Squamous Cell Carcinoma - An Immunohistochemical Study.","authors":"Vijayalaxmi, Sunil S Mishra, N C Sangamesh","doi":"10.4103/ccd.ccd_521_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the most prevalent carcinoma of the head-and-neck region. Despite advanced tissue diagnosis, the survival period remains at 5 years. New molecular and cell markers are under investigation to improve survival rate.</p><p><strong>Objective: </strong>The objective of this study was to assess angiogenic activity by analyzing CD105 microvascular density (MVD) count in different histologic grades of OSCC.</p><p><strong>Subjects and methods: </strong>Sixty samples are categorized into four groups. Immunohistochemical method with anti-CD105 was used for analyzing MVD.</p><p><strong>Results: </strong>The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. A highly significant correlation is observed among different groups of OSCC samples.</p><p><strong>Conclusion: </strong>CD105 is a predictive marker for neoangiogenesis in OSCC.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"16 2","pages":"94-98"},"PeriodicalIF":1.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338458/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary Clinical Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ccd.ccd_521_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Oral squamous cell carcinoma (OSCC) is the most prevalent carcinoma of the head-and-neck region. Despite advanced tissue diagnosis, the survival period remains at 5 years. New molecular and cell markers are under investigation to improve survival rate.
Objective: The objective of this study was to assess angiogenic activity by analyzing CD105 microvascular density (MVD) count in different histologic grades of OSCC.
Subjects and methods: Sixty samples are categorized into four groups. Immunohistochemical method with anti-CD105 was used for analyzing MVD.
Results: The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. A highly significant correlation is observed among different groups of OSCC samples.
Conclusion: CD105 is a predictive marker for neoangiogenesis in OSCC.
期刊介绍：
The journal Contemporary Clinical Dentistry (CCD) (Print ISSN: 0976-237X, E-ISSN:0976- 2361) is peer-reviewed journal published on behalf of Maharishi Markandeshwar University and issues are published quarterly in the last week of March, June, September and December. The Journal publishes Original research papers, clinical studies, case series strictly of clinical interest. Manuscripts are invited from all specialties of Dentistry i.e. Conservative dentistry and Endodontics, Dentofacial orthopedics and Orthodontics, Oral medicine and Radiology, Oral pathology, Oral surgery, Orodental diseases, Pediatric Dentistry, Periodontics, Clinical aspects of Public Health dentistry and Prosthodontics. Review articles are not accepted. Review, if published, will only be by invitation from eminent scholars and academicians of National and International repute in the field of Medical/Dental education.
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