Ke-Ming Ning, Wen-Bo Xu, Yi-Han Wang, Lei Lei, Wang-Si-Jiao Shen, Zhao-Ying Liu
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引用次数: 0
Abstract
Gamma-aminobutyric acid receptors (GABARs) primarily function by suppressing inflammatory responses, modulating neuronal excitability, and maintaining intracellular homeostasis, whereas N-methyl-D-aspartate receptors (NMDARs) play a key role in mediating pathological processes through the regulation of excitatory neurotransmission and immune responses. Viral infections have the capacity to modify the expression and functionality of these receptors, either directly or indirectly, thereby contributing to dysregulation within the neurological and immune systems and triggering a range of disease states. This review offers a comprehensive analysis of the mechanisms through which various viral infections interact with GABARs and NMDARs, emphasizing the possible intricate roles these receptors play in viral pathogenesis. Additionally, it underscores their potential as therapeutic targets for antiviral interventions, particularly in addressing immune dysregulation and neurological disorders.
γ -氨基丁酸受体（gabar）主要通过抑制炎症反应、调节神经元兴奋性和维持细胞内稳态发挥作用，而n -甲基- d -天冬氨酸受体（NMDARs）则通过调节兴奋性神经传递和免疫反应在介导病理过程中发挥关键作用。病毒感染能够直接或间接地改变这些受体的表达和功能，从而导致神经系统和免疫系统的失调，引发一系列疾病状态。本文全面分析了各种病毒感染与gabar和NMDARs相互作用的机制，强调了这些受体在病毒发病机制中可能发挥的复杂作用。此外，它强调了它们作为抗病毒干预治疗靶点的潜力，特别是在解决免疫失调和神经系统疾病方面。
期刊介绍：
Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our understanding of the immunopathology of human disease and/or change clinical practice.
The journal is focused on translational and clinical immunology and is among the foremost journals in this field, attracting high-quality papers from across the world. Translation is viewed as a process of applying ideas, insights and discoveries generated through scientific studies to the treatment, prevention or diagnosis of human disease. Clinical immunology has evolved as a field to encompass the application of state-of-the-art technologies such as next-generation sequencing, metagenomics and high-dimensional phenotyping to understand mechanisms that govern the outcomes of clinical trials.
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