Influence of Genomic Ancestry and Other Traditional Risk Factors on the Prevalence of Diabetic Peripheral Neuropathy in Admixed Individuals With Type 1 Diabetes in Brazil: A Pioneer Multicenter Study

IF 3.2 3区医学 Q1 CLINICAL NEUROLOGY

Journal of the Peripheral Nervous System Pub Date : 2025-08-13 DOI:10.1111/jns.70049

Cejana Hamu Aguiar, Hermelinda Cordeiro Pedrosa, Lucianne Righeti Monteiro Tannus, Livia Leite Ferreira, Dayse Silva, Luís Cristóvão Porto, Carlos Antonio Negrato, Marilia Brito Gomes

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引用次数: 0

Abstract

Aims

To assess the influence of genomic ancestry (GA) and other traditional risk factors on the prevalence of diabetic peripheral neuropathy (DPN) in admixed Brazilian individuals with type 1 diabetes (T1D).

Methods

This cross-sectional, multicenter, pioneer study was conducted in 14 public clinics in 10 Brazilian cities. From 1760 individuals, 1732 were included (98.4%), aged 29.9 ± 11.9 years, diabetes duration 15.4 ± 9.2 years, 968 females (55.9%), 939 (55.7%) self-reported as White. DPN was evaluated by the validated neuropathy disability score (NDS) and neuropathy symptoms score (NSS).

Results

The prevalence of DPN was 14.8%. In hierarchical multivariate logistic regression, the covariates associated with DPN were age, diabetes duration, HbA1c, type of health care insurance, insulin therapeutic regimen, number of yearly clinical visits, low exercise practice rates, hypertension, dyslipidemia, heart rate, statin use, uric acid levels, lower health-related quality of life, presence of diabetic retinopathy, and amputations. Among the sociodemographic characteristics, African GA, a contemporary emerging factor, showed the highest association.

Conclusions

DPN was related to several comorbidities, diabetes-related complications, and lower health-related quality of life. These individuals were young, implying a high lifetime cost of this disease. The association with the emerging factor African GA warrants further studies involving other admixed populations.

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基因组血统和其他传统危险因素对巴西1型糖尿病混合个体糖尿病周围神经病变患病率的影响：一项开创性的多中心研究

目的评估基因组血统（GA）和其他传统危险因素对巴西混合1型糖尿病（T1D）患者糖尿病周围神经病变（DPN）患病率的影响。方法在巴西10个城市的14家公立诊所进行了横断面、多中心、开拓性研究。1760例中，1732例（98.4%），年龄29.9±11.9岁，糖尿病病程15.4±9.2年，女性968例（55.9%），939例（55.7%）。采用神经病变失能评分（NDS）和神经病变症状评分（NSS）对DPN进行评估。结果DPN患病率为14.8%。在分层多变量logistic回归中，与DPN相关的协变量为年龄、糖尿病病程、HbA1c、医疗保险类型、胰岛素治疗方案、每年临床就诊次数、低运动练习率、高血压、血脂异常、心率、他汀类药物使用、尿酸水平、较低的健康相关生活质量、糖尿病视网膜病变的存在和截肢。在社会人口学特征中，当代新兴因素非洲GA的相关性最高。结论DPN与几种合并症、糖尿病相关并发症和较低的健康相关生活质量有关。这些人都很年轻，这意味着这种疾病的终生成本很高。与新兴因素非洲GA的关联值得涉及其他混合种群的进一步研究。

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来源期刊

Journal of the Peripheral Nervous System 医学-临床神经学

CiteScore

6.10

自引率

7.90%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society. Founded in 1996, it is the scientific journal of choice for clinicians, clinical scientists and basic neuroscientists interested in all aspects of biology and clinical research of peripheral nervous system disorders. The Journal of the Peripheral Nervous System is a peer-reviewed journal that publishes high quality articles on cell and molecular biology, genomics, neuropathic pain, clinical research, trials, and unique case reports on inherited and acquired peripheral neuropathies. Original articles are organized according to the topic in one of four specific areas: Mechanisms of Disease, Genetics, Clinical Research, and Clinical Trials. The journal also publishes regular review papers on hot topics and Special Issues on basic, clinical, or assembled research in the field of peripheral nervous system disorders. Authors interested in contributing a review-type article or a Special Issue should contact the Editorial Office to discuss the scope of the proposed article with the Editor-in-Chief.