Prevalence and associated risk factors of human immunodeficiency virus-associated Kaposi’s sarcoma among patients receiving care at Cancer Diseases Hospital, Lusaka, Zambia

Q2 Nursing

International Journal of Africa Nursing Sciences Pub Date : 2025-01-01 DOI:10.1016/j.ijans.2025.100880

Stella Mankuce , Victoria Mwiinga-Kalusopa , Ruth Wahila

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Abstract

Introduction

Kaposi’s sarcoma (KS) remains prevalent and among the ten most common cancers in Zambia despite the availability of antiretroviral therapy (ART). The co-occurrence of KS and Human Immunodeficiency virus (HIV) infection poses a significant public health concern due to its aggressive nature and its potential to exacerbate the health challenges faced by individuals already grappling with HIV infection. This study aimed to determine the prevalence and associated risk factors of HIV-associated KS among patients receiving care at Cancer Diseases Hospital (CDH).

Materials and methods

This cross-sectional study, included 93 patients with KS, irrespective of HIV status. Data were analyzed using STATA version 16.0 MP. Chi-square, Fisher’s exact tests and multivariable binary logistic regression analysis were employed. A p-value of 0.05 was considered significant.

Results

Unmarried individuals exhibited significant odds of developing KS (aOR = 13.1, 95 % CI: 5.72–30.2, p < 0.001). Monthly income of ≤ K5000 Zambian Kwacha had higher odds of developing HIV-associated KS (aOR = 5.92, 95 % CI: 3.22–10.9, p < 0.001). Residence outside Lusaka had a markedly elevated risk (aOR = 11.9, 95 % CI: 4.46–31.8, p < 0.001). Cigarette smoking had increased risk of HIV-associated KS (aOR = 13.9, 95 % CI: 6.29–30.6, p < 0.001).

Conclusion

The results of this study highlight the need for targeted public health interventions, including routine HIV prevention strategies, strengthened tobacco control policies, and economic empowerment programs, to enhance health outcomes and mitigate the burden of HIV-associated KS.

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在赞比亚卢萨卡癌症疾病医院接受治疗的患者中，人类免疫缺陷病毒相关的卡波西肉瘤的患病率及相关危险因素

尽管有抗逆转录病毒疗法（ART），但卡波西肉瘤（KS）在赞比亚仍然很流行，是十大最常见的癌症之一。KS和人类免疫缺陷病毒（HIV）感染的共同发生引起了重大的公共卫生关注，因为它具有侵袭性，并且有可能加剧已经与HIV感染作斗争的个体面临的健康挑战。本研究旨在确定在癌症疾病医院（CDH）接受治疗的患者中hiv相关KS的患病率和相关危险因素。材料和方法本横断面研究纳入93例KS患者，不论HIV状态如何。数据分析使用STATA 16.0 MP版本。采用卡方检验、Fisher精确检验和多变量二元logistic回归分析。p值为0.05被认为是显著的。结果已婚人群发生KS的几率显著(aOR = 13.1, 95% CI: 5.72 ~ 30.2, p <；0.001)。月收入≤K5000的赞比亚克瓦查患艾滋病相关KS的几率更高(aOR = 5.92, 95% CI: 3.22-10.9, p <；0.001)。居住在卢萨卡以外地区的风险明显升高(aOR = 11.9, 95% CI: 4.46-31.8, p <；0.001)。吸烟增加hiv相关KS的风险(aOR = 13.9, 95% CI: 6.29-30.6, p <；0.001)。结论本研究结果强调需要有针对性的公共卫生干预措施，包括常规艾滋病毒预防策略，加强烟草控制政策和经济赋权计划，以提高健康结果并减轻艾滋病毒相关KS的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Africa Nursing Sciences Nursing-Nursing (all)

CiteScore

2.40

自引率

0.00%

发文量

114

审稿时长

21 weeks

期刊介绍： International Journal of Africa Nursing Sciences (IJANS) is an international scientific journal published by Elsevier. The broad-based journal was founded on two key tenets, i.e. to publish the most exciting research with respect to the subjects of Nursing and Midwifery in Africa, and secondly, to advance the international understanding and development of nursing and midwifery in Africa, both as a profession and as an academic discipline. The fully refereed journal provides a forum for all aspects of nursing and midwifery sciences, especially new trends and advances. The journal call for original research papers, systematic and scholarly review articles, and critical papers which will stimulate debate on research, policy, theory or philosophy of nursing as related to nursing and midwifery in Africa, technical reports, and short communications, and which will meet the journal''s high academic and ethical standards. Manuscripts of nursing practice, education, management, and research are encouraged. The journal values critical scholarly debate on issues that have strategic significance for educators, practitioners, leaders and policy-makers of nursing and midwifery in Africa. The journal publishes the highest quality scholarly contributions reflecting the diversity of nursing, and is also inviting international scholars who are engaged with nursing and midwifery in Africa to contribute to the journal. We will only publish work that demonstrates the use of rigorous methodology as well as by publishing papers that highlight the theoretical underpinnings of nursing and midwifery as it relates to the Africa context.