{"title":"Der Darm als Schlüssel zur ganzheitlichen Gesundheit","authors":"Malte Herberhold","doi":"10.1016/S1615-9071(25)00074-7","DOIUrl":null,"url":null,"abstract":"<div><div>The intestine is much more than just a digestive organ: as an immunological, neurological and metabolic control centre, it interacts closely with almost all body systems. Through its microbiome, intestinal barrier and production of bioactive substances such as short-chain fatty acids, neurotransmitters and vitamins, the intestine influences central processes of immune regulation, energy metabolism and neural communication.</div><div>A disrupted intestinal barrier – often in the context of leaky gut syndrome – and microbial dysbiosis are increasingly suspected of being involved in the development of systemic and chronic inflammatory diseases. These include autoimmune diseases, neuroinflammatory disorders, metabolic syndrome and musculoskeletal complaints. Nutrition, lifestyle factors, perinatal imprinting and environmental conditions have a significant influence on the integrity of the intestinal barrier and the diversity of the microbiome. Certain food components such as lectins, gluten or highly processed carbohydrates can increase intestinal permeability, while a varied diet rich in fibre and fermentable foods has a protective effect.</div><div>In osteopathic medicine, viewing the intestine as a functional centre opens up a relevant therapeutic field. Visceral, neural and fascial techniques in particular can influence the gut-brain axis and vegetative regulatory mechanisms. The integrative osteopathic approach thus offers effective options for treating functional disorders and chronic conditions in the context of systemic imbalances.</div></div>","PeriodicalId":100996,"journal":{"name":"Osteopathische Medizin","volume":"26 3","pages":"Pages 31-37"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Osteopathische Medizin","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1615907125000747","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The intestine is much more than just a digestive organ: as an immunological, neurological and metabolic control centre, it interacts closely with almost all body systems. Through its microbiome, intestinal barrier and production of bioactive substances such as short-chain fatty acids, neurotransmitters and vitamins, the intestine influences central processes of immune regulation, energy metabolism and neural communication.
A disrupted intestinal barrier – often in the context of leaky gut syndrome – and microbial dysbiosis are increasingly suspected of being involved in the development of systemic and chronic inflammatory diseases. These include autoimmune diseases, neuroinflammatory disorders, metabolic syndrome and musculoskeletal complaints. Nutrition, lifestyle factors, perinatal imprinting and environmental conditions have a significant influence on the integrity of the intestinal barrier and the diversity of the microbiome. Certain food components such as lectins, gluten or highly processed carbohydrates can increase intestinal permeability, while a varied diet rich in fibre and fermentable foods has a protective effect.
In osteopathic medicine, viewing the intestine as a functional centre opens up a relevant therapeutic field. Visceral, neural and fascial techniques in particular can influence the gut-brain axis and vegetative regulatory mechanisms. The integrative osteopathic approach thus offers effective options for treating functional disorders and chronic conditions in the context of systemic imbalances.