Severe Acute Localized Reaction/Pseudosepsis in Patients With Knee Osteoarthritis Receiving Injections of Hyaluronic Acid: A Targeted Literature Review.
Seth Lawrence Sherman, Wilson Ngai, Kevin Steele, Jean-Paul Collet, John D A Kelly
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引用次数: 0
Abstract
Background: Hyaluronic acid injections for knee osteoarthritis patients can result in pseudosepsis. A targeted literature review was conducted to determine the rate of pseudosepsis in patients receiving intra-articular hyaluronic acid, particularly hylan G-F 20 (SYNVISC®).
Materials and methods: Articles were identified through Embase using predefined search strategies. Pseudosepsis event rate was calculated by dividing the number of reported events by the total number of intra-articular injections.
Results: The pseudosepsis event rate ranged from 0% to 5.6% per injection; most treatment groups had an event rate of ≤2% per injection.
Conclusion: Pseudosepsis event rates were low across studies for patients treated with hyaluronic acid, including hylan G-F 20.
期刊介绍：
For over 40 years, Orthopedics, a bimonthly peer-reviewed journal, has been the preferred choice of orthopedic surgeons for clinically relevant information on all aspects of adult and pediatric orthopedic surgery and treatment. Edited by Robert D''Ambrosia, MD, Chairman of the Department of Orthopedics at the University of Colorado, Denver, and former President of the American Academy of Orthopaedic Surgeons, as well as an Editorial Board of over 100 international orthopedists, Orthopedics is the source to turn to for guidance in your practice.
The journal offers access to current articles, as well as several years of archived content. Highlights also include Blue Ribbon articles published full text in print and online, as well as Tips & Techniques posted with every issue.
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