{"title":"mSphere of Influence: Population-level thinking to unravel microbial pathogenicity.","authors":"Amelia E Barber","doi":"10.1128/msphere.00588-24","DOIUrl":null,"url":null,"abstract":"<p><p>Amelia E. Barber works in the field of fungal genomics and pathogenesis. In this mSphere of Influence article, she reflects on how the paper \"Strain heterogeneity in a non-pathogenic <i>Aspergillus</i> fungus highlights factors associated with virulence\" from the group of Antonis Rokas changed her view on the binary characterization of microbes as pathogens or non-pathogens. The work highlights the overlapping virulence traits shared between the two groups and encourages the use of a population-based framework. To understand the full spectrum of microbial pathogenic potential, virulence phenotypes are characterized across a strain population of isolates from \"pathogenic\" species and closely related \"non-pathogens,\" in this case revealing a continuum rather than a clear distinction.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0058824"},"PeriodicalIF":3.1000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482144/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00588-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Amelia E. Barber works in the field of fungal genomics and pathogenesis. In this mSphere of Influence article, she reflects on how the paper "Strain heterogeneity in a non-pathogenic Aspergillus fungus highlights factors associated with virulence" from the group of Antonis Rokas changed her view on the binary characterization of microbes as pathogens or non-pathogens. The work highlights the overlapping virulence traits shared between the two groups and encourages the use of a population-based framework. To understand the full spectrum of microbial pathogenic potential, virulence phenotypes are characterized across a strain population of isolates from "pathogenic" species and closely related "non-pathogens," in this case revealing a continuum rather than a clear distinction.
Amelia E. Barber在真菌基因组学和发病机制领域工作。在这篇mSphere of Influence文章中，她反思了Antonis Rokas小组的论文“非致病性曲霉真菌的菌株异质性突出了与毒力相关的因素”如何改变了她对微生物作为病原体或非病原体的二元特征的看法。这项工作强调了两组之间共有的重叠毒力特征，并鼓励使用基于人群的框架。为了了解微生物致病潜力的全谱，毒力表型在“致病”物种和密切相关的“非病原体”分离的菌株种群中被表征，在这种情况下揭示了一个连续体而不是一个明确的区别。
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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