From analytical interference to the detection of intoxication.

IF 1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY

Annals of Clinical Biochemistry Pub Date : 2025-08-12 DOI:10.1177/00045632251367247

Sonali Suresh Karnani-Khemlani, María José de la Vega-Prieto, Juana Reyes Padrón-Morales, Fuensanta Gómez-Bernal, Elene Laburu-Dañobeitia, Marta Rodríguez-García, Darío Cabana-Ramos, Sergio Luis-Lima

引用次数: 0

Abstract

This article describes the case of a 66-year-old man who attended the emergency department due to a decrease in the level of consciousness. When determining creatinine in blood plasma using the enzymatic method on the Roche cobas c702® (Roche Diagnostics, Manheim, Germany), an undetectable creatinine value was obtained. Recently, both the literature and the manufacturer of the assay have described that the toxic metabolite of paracetamol, N-acetyl-p-benzoquinone imine, interferes with the enzymatic measurement of creatinine. Therefore, the concentration of paracetamol was determined in the same sample confirming toxic levels. On the other hand, the determination of creatinine by the Jaffe method did not present such interference. This case underlines the importance of determining creatinine by non-enzymatic methods in cases of paracetamol overdose in order to correctly assess renal function.

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从分析干扰到中毒检测。

这篇文章描述了一个66岁的男子谁出席了急诊室由于意识水平下降。当使用罗氏cobas c702®（罗氏诊断，曼海姆，德国）的酶促法测定血浆肌酐时，获得了无法检测到的肌酐值。最近，文献和该检测方法的制造商都描述了扑热息痛的有毒代谢物n -乙酰基-对苯醌亚胺会干扰肌酐的酶促测量。因此，在同一样品中测定了扑热息痛的浓度，确认了毒性水平。另一方面，用Jaffe法测定肌酐不存在这种干扰。本病例强调了在扑热息痛过量的情况下，用非酶法测定肌酐的重要性，以便正确评估肾功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).