{"title":"Is There Any Association Between Periodontitis and Prostatic Alterations? A Systematic Review.","authors":"Beatriz Rodrigues Risuenho Peinado, Rayssa Maitê Farias Nazário, Deborah Ribeiro Frazão, Yago Gecy de Sousa Né, Leonardo Oliveira Bittencourt, Nathália Carolina Fernandes Fagundes, Caio Melo Mesquita, Cassiano Kuchenbecker Rösing, Renata Duarte de Souza-Rodrigues, Luiz Renato Paranhos, Lucianne Cople Maia, Rafael Rodrigues Lima","doi":"10.1002/pros.70029","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The prostate plays a crucial role in male reproduction but is susceptible to diseases such as prostate cancer. Periodontitis, as an inflammatory disease, has the potential to modulate systemic conditions. This systematic review aimed to evaluate the association between periodontitis and prostatic alterations.</p><p><strong>Methods: </strong>The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines and registered in the PROSPERO database (CRD42024614333). Observational studies comparing the presence of periodontitis in men with and without prostatic alterations were included. The search strategy was applied to databases such as PubMed, Scopus, Embase, Web of Science and Lilacs, as well as gray literature (OpenGrey and Google Scholar). The selection of studies and data extraction were carried out independently by two reviewers. Methodological quality was assessed using the tools of the Joanna Briggs Institute, and confounding factors were analyzed using multivariate models, where applicable.</p><p><strong>Results: </strong>A total of 769 references were identified, and 14 studies were included. Most studies indicated a significant association between periodontitis and prostate cancer, with a higher risk in patients with periodontal disease. Associations with BPH and chronic prostatitis were also observed in fewer studies. However, methodological limitations, such as inadequate control of confounding factors (e.g. smoking, genetics and age), heterogeneity in diagnostic criteria and reliance on self-reported data, increased the risk of bias. Many studies did not adequately adjust for confounding factors, compromising the robustness of the evidence.</p><p><strong>Conclusion: </strong>Thus, the findings suggest a potential association between periodontitis and prostatic alterations, especially prostate cancer.</p>","PeriodicalId":54544,"journal":{"name":"Prostate","volume":" ","pages":"1369-1385"},"PeriodicalIF":2.5000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452812/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostate","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pros.70029","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The prostate plays a crucial role in male reproduction but is susceptible to diseases such as prostate cancer. Periodontitis, as an inflammatory disease, has the potential to modulate systemic conditions. This systematic review aimed to evaluate the association between periodontitis and prostatic alterations.
Methods: The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines and registered in the PROSPERO database (CRD42024614333). Observational studies comparing the presence of periodontitis in men with and without prostatic alterations were included. The search strategy was applied to databases such as PubMed, Scopus, Embase, Web of Science and Lilacs, as well as gray literature (OpenGrey and Google Scholar). The selection of studies and data extraction were carried out independently by two reviewers. Methodological quality was assessed using the tools of the Joanna Briggs Institute, and confounding factors were analyzed using multivariate models, where applicable.
Results: A total of 769 references were identified, and 14 studies were included. Most studies indicated a significant association between periodontitis and prostate cancer, with a higher risk in patients with periodontal disease. Associations with BPH and chronic prostatitis were also observed in fewer studies. However, methodological limitations, such as inadequate control of confounding factors (e.g. smoking, genetics and age), heterogeneity in diagnostic criteria and reliance on self-reported data, increased the risk of bias. Many studies did not adequately adjust for confounding factors, compromising the robustness of the evidence.
Conclusion: Thus, the findings suggest a potential association between periodontitis and prostatic alterations, especially prostate cancer.
背景：前列腺在男性生殖中起着至关重要的作用，但也易患前列腺癌等疾病。牙周炎作为一种炎症性疾病，具有调节全身状况的潜力。本系统综述旨在评估牙周炎和前列腺改变之间的关系。方法：按照系统评价和元分析首选报告项目（PRISMA）指南进行综述，并在PROSPERO数据库（CRD42024614333）中注册。观察性研究比较了有和没有前列腺改变的男性牙周炎的存在。该搜索策略应用于PubMed、Scopus、Embase、Web of Science和Lilacs等数据库，以及灰色文献（OpenGrey和谷歌Scholar）。研究的选择和数据的提取由两位审稿人独立进行。使用Joanna Briggs研究所的工具评估方法学质量，并在适用的情况下使用多变量模型分析混杂因素。结果：共纳入文献769篇，纳入研究14篇。大多数研究表明，牙周炎和前列腺癌之间存在显著关联，牙周病患者患前列腺癌的风险更高。在少数研究中也观察到前列腺增生与慢性前列腺炎的关系。然而，方法学上的局限性，如对混杂因素（如吸烟、遗传和年龄）控制不足、诊断标准的异质性和对自我报告数据的依赖，增加了偏倚的风险。许多研究没有充分调整混杂因素，损害了证据的稳健性。结论：因此，研究结果提示牙周炎与前列腺病变，特别是前列腺癌之间存在潜在的联系。
期刊介绍：
The Prostate is a peer-reviewed journal dedicated to original studies of this organ and the male accessory glands. It serves as an international medium for these studies, presenting comprehensive coverage of clinical, anatomic, embryologic, physiologic, endocrinologic, and biochemical studies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
