[Exploring the causal relationship between leukocyte telomere length and prostatitis, orchitis, and epididymitis based on a two-sample Mendelian randomization].

Q4 Medicine

中华男科学杂志 Pub Date : 2025-04-01

Dan-Yang Li, Shun Yu, Bo-Hui Yang, Jun-Bao Zhang, Guo-Chen Yin, Lin-Na Wu, Qin-Zuo Dong, Jin-Long Xu, Shu-Ping Ning, Rong Zhao

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引用次数: 0

Abstract

Objective: To investigate the genetic causal relationship of leukocyte telomere length (LTL) with prostatitis, orchitis and epididymitis by two-sample Mendelian randomization (MR).

Methods: Using LTL as the exposure factor and prostatitis, orchitis and epididymitis as outcome factors, we mined the Database of Genome-Wide Association Studies (GWAS). Then, we analyzed the causal relationship of LTL with prostatitis, orchitis and epididymitis by Mendelian randomization using inverse variance weighting (IVW) as the main method and weighted median and MR-Egger regression as auxiliary methods, determined the horizontal multiplicity by MR-Egger intercept test, and conducted sensitivity analysis using the leaving-one-out method.

Results: A total of 121 related single nucleotide polymorphisms (SNPs) were identified in this study. IVW showed LTL to be a risk factor for prostatitis (OR = 1.383, 95% CI: 1.044－1.832, P = 0.024), and for orchitis and epididymitis as well (OR = 1.770, 95% CI: 1.275－2.456, P = 0.000 6).

Conclusion: Genetic evidence from Mendelian randomized analysis indicates that shortening of LTL reduces the risk of prostatitis, orchitis and epididymitis.

本刊更多论文

[基于两样本孟德尔随机化，探讨白细胞端粒长度与前列腺炎、睾丸炎和附睾炎之间的因果关系]。

目的：采用双样本孟德尔随机化（MR）方法探讨白细胞端粒长度（LTL）与前列腺炎、睾丸炎和附睾炎的遗传因果关系。方法：以LTL为暴露因素，前列腺炎、睾丸炎和附睾炎为结局因素，挖掘全基因组关联研究数据库（GWAS）。然后，我们采用孟德尔随机化方法，以逆方差加权（IVW）为主要方法，加权中位数和MR-Egger回归为辅助方法，分析LTL与前列腺炎、睾丸炎和附睾炎的因果关系，采用MR-Egger截距检验确定水平多重度，并采用留一法进行敏感性分析。结果：共鉴定出121个相关的单核苷酸多态性（snp）。IVW显示LTL是前列腺炎（OR = 1.383, 95% CI: 1.044-1.832, P = 0.024）、睾丸炎和附睾炎（OR = 1.770, 95% CI: 1.75 -2.456, P = 0.0006）的危险因素。结论：孟德尔随机分析的遗传学证据表明，LTL缩短可降低前列腺炎、睾丸炎和附睾炎的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华男科学杂志 Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

5367

期刊介绍： National journal of andrology was founded in June 1995. It is a core journal of andrology and reproductive medicine, published monthly, and is publicly distributed at home and abroad. The main columns include expert talks, monographs (basic research, clinical research, evidence-based medicine, traditional Chinese medicine), reviews, clinical experience exchanges, case reports, etc. Priority is given to various fund-funded projects, especially the 12th Five-Year National Support Plan and the National Natural Science Foundation funded projects. This journal is included in about 20 domestic databases, including the National Science and Technology Paper Statistical Source Journal (China Science and Technology Core Journal), the Source Journal of the China Science Citation Database, the Statistical Source Journal of the China Academic Journal Comprehensive Evaluation Database (CAJCED), the Full-text Collection Journal of the China Journal Full-text Database (CJFD), the Overview of the Chinese Core Journals (2017 Edition), and the Source Journal of the Top Academic Papers of China's Fine Science and Technology Journals (F5000). It has been included in the full text of the American Chemical Abstracts, the American MEDLINE, the American EBSCO, and the database.