[Moxibustion combined with low-dose tadalafil for diabetes mellitus-induced erectile dysfunction: A prospective, single-center, three-arm randomized controlled trial].

Q4 Medicine

中华男科学杂志 Pub Date : 2025-01-01

Tao Liu, Zhao-Xu Yang, Yan Xu, Qi Zhao, Xue Liu, Xin-Fei Huang, Zhi-Xing Sun, Yun Chen, Jian-Huai Chen

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引用次数: 0

Abstract

Objective: To investigate the clinical efficacy of moxibustion (Mox) combined with low-dose tadalafil (TAD) in the treatment of diabetes mellitus-induced erectile dysfunction (DMED) with the syndrome of Qi deficiency and blood stasis.

Methods: According to the inclusion and exclusion criteria, we selected 90 patients with DMED for this trial and equally randomized them into a Mox, a TAD, and a Mox combined with TAD (Mox+TAD) group to be treated by mild Mox applied to the acupoints Zusanli, Sanyinjiao and Yinlingquan qd alt, oral medication with low-dose TAD at 5 mg per dose qd, and combination of the above two therapies, respectively, all for 4 weeks. We obtained from the patients their IIEF-5 scores, traditional Chinese medicine (TCM) symptoms scores, Erectile Hardness Scale (EHS) scores, corpus cavernosal hemodynamic indexes, and the peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) of the corpus cavernosal arteries before and after treatment, and compared them among the three groups.

Results: The total effectiveness rate was significantly higher in the Mox+TAD (90.0%) than in the Mox (46.7%) and TAD groups (60.0%) (P< 0.05). Compared with the baseline, the IIEF-5 and EHS scores were increased, while the TCM symptoms scores decreased in all the three groups after treatment, more significantly in the Mox+TAD group than in the other two (P< 0.05). And the PSV and RI were remarkably increased, while the EDV decreased (P< 0.05) in all the three groups (P< 0.05) after treatment, with PSV even higher in the Mox+TAD than in the Mox and TAD groups (P< 0.05).

Conclusion: Moxibustion combined with tadalafil has a definite efficacy and safety for the treatment of DMED, which can effectively improve the erectile function of the patients by increasing penile blood supply, benefiting qi and activating blood circulation.

本刊更多论文

艾灸联合低剂量他达拉非治疗糖尿病性勃起功能障碍：一项前瞻性、单中心、三组随机对照试验。

目的：探讨艾灸联合小剂量他达拉非治疗糖尿病性勃起功能障碍（DMED）气虚血瘀证的临床疗效。方法：根据纳入和排除标准，选择90例DMED患者，随机分为莫司组、莫司组、莫司联合莫司组（莫司+莫司组），分别给予轻度莫司于足三里、三阴交、银灵泉穴每日一次、口服低剂量莫司5 mg /次、联合用药，疗程均为4周。获取患者的IIEF-5评分、中医症状评分、勃起硬度评分、海绵体血流动力学指标以及治疗前后海绵体动脉的峰值收缩速度（PSV）、舒张末期速度（EDV）和阻力指数（RI），并进行比较。结果：Mox+TAD组总有效率（90.0%）显著高于Mox组（46.7%）和TAD组（60.0%）（P< 0.05）。治疗后三组患者IIEF-5、EHS评分均较治疗前升高，中医症状评分均下降，且Mox+TAD组较治疗前显著（P< 0.05）。三组治疗后PSV和RI均显著升高，EDV均显著降低（P< 0.05），且Mox+TAD组PSV高于Mox和TAD组（P< 0.05）。结论：艾灸联合他达拉非治疗DMED疗效确切，安全性高，可通过增加阴茎血供，益气活血，有效改善患者勃起功能。

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来源期刊

中华男科学杂志 Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

5367

期刊介绍： National journal of andrology was founded in June 1995. It is a core journal of andrology and reproductive medicine, published monthly, and is publicly distributed at home and abroad. The main columns include expert talks, monographs (basic research, clinical research, evidence-based medicine, traditional Chinese medicine), reviews, clinical experience exchanges, case reports, etc. Priority is given to various fund-funded projects, especially the 12th Five-Year National Support Plan and the National Natural Science Foundation funded projects. This journal is included in about 20 domestic databases, including the National Science and Technology Paper Statistical Source Journal (China Science and Technology Core Journal), the Source Journal of the China Science Citation Database, the Statistical Source Journal of the China Academic Journal Comprehensive Evaluation Database (CAJCED), the Full-text Collection Journal of the China Journal Full-text Database (CJFD), the Overview of the Chinese Core Journals (2017 Edition), and the Source Journal of the Top Academic Papers of China's Fine Science and Technology Journals (F5000). It has been included in the full text of the American Chemical Abstracts, the American MEDLINE, the American EBSCO, and the database.