{"title":"Engineering the electronic structure of Fe-MoO<sub>2</sub>@PEG to increase sonodynamic and multi-nanozyme activities for anticancer therapy.","authors":"Rongrong Mu, Wenhui Song, Zili Li, Yuting Pan, Jingwei Liu, Fengyu Qu, Huiming Lin","doi":"10.1016/j.jcis.2025.138626","DOIUrl":null,"url":null,"abstract":"<p><p>Both sonodynamic therapy (SDT) and nanozymes can be considered specialized forms of catalysis, which are related to the electron structure. In this work, Fe doping was employed to introduce electronic localization and spin polarization toward porous MoO<sub>2</sub> nanospheres to improve the anticancer catalytic efficiency. All the Fe atoms are single-distributed to substitute for some lattice positions of Mo. Compared with MoO<sub>2</sub>@PEG, MoO<sub>2</sub>/Fe@PEG results in a 2.8-fold increase in ROS generation, which is attributed to spin polarization. This phenomenon enhances charge separation, increases conductivity, and promotes O₂ adsorption, thereby significantly improving the ROS production efficiency. Furthermore, MoO<sub>2</sub>/Fe@PEG also has superior mimic-catalase (CAT) activity (318,467 U g<sup>-1</sup>), which is even greater than that of natural catalase (220,834 U g<sup>-1</sup>). Compare with MoO<sub>2</sub>@PEG Fe doping increased the activity by 76.0 times because electron localization can decrease the free energy of the redox reaction. This novel CAT ability can convert endogenous H<sub>2</sub>O<sub>2</sub> into O<sub>2</sub>, alleviating tumor hypoxia and increasing ROS production. Notably, MoO₂/Fe@PEG also mimics GSH oxidase and NADPH oxidase (NOX) activities to consume GSH and restrain its regeneration at the same time, contributing to oxidative stress. The synergistic effects of SDT and multiple enzymes not only exhibit potent tumor inhibition but also elicit a robust immune response to prevent metastasis and recurrence.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"701 ","pages":"138626"},"PeriodicalIF":9.7000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Colloid and Interface Science","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.jcis.2025.138626","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Both sonodynamic therapy (SDT) and nanozymes can be considered specialized forms of catalysis, which are related to the electron structure. In this work, Fe doping was employed to introduce electronic localization and spin polarization toward porous MoO2 nanospheres to improve the anticancer catalytic efficiency. All the Fe atoms are single-distributed to substitute for some lattice positions of Mo. Compared with MoO2@PEG, MoO2/Fe@PEG results in a 2.8-fold increase in ROS generation, which is attributed to spin polarization. This phenomenon enhances charge separation, increases conductivity, and promotes O₂ adsorption, thereby significantly improving the ROS production efficiency. Furthermore, MoO2/Fe@PEG also has superior mimic-catalase (CAT) activity (318,467 U g-1), which is even greater than that of natural catalase (220,834 U g-1). Compare with MoO2@PEG Fe doping increased the activity by 76.0 times because electron localization can decrease the free energy of the redox reaction. This novel CAT ability can convert endogenous H2O2 into O2, alleviating tumor hypoxia and increasing ROS production. Notably, MoO₂/Fe@PEG also mimics GSH oxidase and NADPH oxidase (NOX) activities to consume GSH and restrain its regeneration at the same time, contributing to oxidative stress. The synergistic effects of SDT and multiple enzymes not only exhibit potent tumor inhibition but also elicit a robust immune response to prevent metastasis and recurrence.
声动力疗法(SDT)和纳米酶都可以被认为是特殊形式的催化,这与电子结构有关。本文采用Fe掺杂的方法对多孔MoO2纳米球引入电子局域化和自旋极化,以提高其抗癌催化效率。所有的Fe原子都是单分布的,以取代Mo的一些晶格位置。与MoO2@PEG相比,MoO2/Fe@PEG导致ROS生成增加2.8倍,这归因于自旋极化。这种现象增强了电荷分离,增加了电导率,促进了O₂的吸附,从而显著提高了ROS的生产效率。此外,MoO2/Fe@PEG还具有更高的模拟过氧化氢酶(CAT)活性(318,467 U g-1),甚至高于天然过氧化氢酶(220,834 U g-1)。与MoO2@PEG相比,Fe掺杂使活性提高了76.0倍,这是因为电子定位降低了氧化还原反应的自由能。这种新的CAT能力可以将内源性H2O2转化为O2,缓解肿瘤缺氧,增加ROS的产生。值得注意的是,MoO₂/Fe@PEG还会模仿GSH氧化酶和NADPH氧化酶(NOX)的活性,消耗GSH,同时抑制其再生,从而导致氧化应激。SDT和多种酶的协同作用不仅表现出强大的肿瘤抑制作用,而且引起强大的免疫反应,以防止转移和复发。
期刊介绍:
The Journal of Colloid and Interface Science publishes original research findings on the fundamental principles of colloid and interface science, as well as innovative applications in various fields. The criteria for publication include impact, quality, novelty, and originality.
Emphasis:
The journal emphasizes fundamental scientific innovation within the following categories:
A.Colloidal Materials and Nanomaterials
B.Soft Colloidal and Self-Assembly Systems
C.Adsorption, Catalysis, and Electrochemistry
D.Interfacial Processes, Capillarity, and Wetting
E.Biomaterials and Nanomedicine
F.Energy Conversion and Storage, and Environmental Technologies