Prevalence, Characteristics, and Arrhythmogenic Substrate of Mitral Annular Disjunction Assessed by Cardiac Magnetic Resonance Imaging in Patients With Apparently Idiopathic Ventricular Arrhythmia

IF 1.7 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Arrhythmia Pub Date : 2025-08-10 DOI:10.1002/joa3.70172

Saori Asada, Hiroshi Morita, Norihisa Toh, Takuro Masuda, Akira Ueoka, Masakazu Miyamoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Shinsuke Yuasa

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Abstract

Background

Mitral annular disjunction (MAD) is linked to an increased risk of sudden cardiac death, but its association with ventricular arrhythmias (VAs) in Japanese patients is unclear.

Methods

We retrospectively analyzed 129 Japanese patients with VAs and no overt structural heart disease who underwent echocardiography and cardiac MRI.

Results

MAD was diagnosed in 7.0%, and in 14% of patients with VAs originating from the mitral valve apparatus. MAD was significantly associated with multifocal VAs, late gadolinium enhancement in the papillary muscles, and greater mitral regurgitation.

Conclusion

MAD may be an important arrhythmogenic substrate in apparently idiopathic VAs among Japanese patients.

Abstract Image

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明显特发性室性心律失常患者中二尖瓣环分离的发生率、特征和致心律失常底物的心脏磁共振成像评估

背景：二尖瓣环分离（MAD）与心源性猝死风险增加有关，但其与日本患者室性心律失常（VAs）的关系尚不清楚。方法回顾性分析129例无明显结构性心脏病的日本VAs患者，均行超声心动图和心脏MRI检查。结果7.0%的患者诊断为MAD， 14%的患者诊断为源自二尖瓣装置的VAs。MAD与多灶性VAs、晚期乳头肌钆增强和二尖瓣返流明显相关。结论MAD可能是日本明显特发性VAs患者重要的致心律失常底物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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