Cost-effective chiral auxiliary-assisted remote asymmetric C(sp3)–H alkylation of hydroxamic acid derivatives with glycine derivatives†

Abstract

Visible-light-mediated commercially available and cost-effective chiral auxiliary-assisted radical–radical cross-coupling for the preparation of noncanonical chiral amino acids under base- and metal-free conditions has been reported. The reaction featured a broad substrate scope and excellent enantioselectivity. Besides, the products can be converted to biologically important chiral β-amino alcohols under simple procedures.