Cynthia Liu, Bersa Kelkai, David Wu, Alexander Tatara, Juan Cintron, David J. Mooney* and Benjamin R. Freedman*,
{"title":"Mechanically Active and Antimicrobial Wound Closure Using an Adhesive Hydrogel-Elastomer","authors":"Cynthia Liu, Bersa Kelkai, David Wu, Alexander Tatara, Juan Cintron, David J. Mooney* and Benjamin R. Freedman*, ","doi":"10.1021/acsptsci.5c00341","DOIUrl":null,"url":null,"abstract":"<p >Chronic wounds affect millions worldwide and lead to pain, infection, and impaired quality of life. Current wound sealing technologies for chronic wound care remain largely palliative, with poor adhesion, weak mechanical properties, and limited ability to deliver therapeutics. Emerging technologies, including autologous blood products, growth factor-enhanced scaffolds, and artificial skin, although clinically successful, are limited from widespread adoption by the high cost of production and challenging clinical workflow. Here, we present a tough adhesive-elastomer wound care technology that is mechanically robust to approximate wound edges, can adhere strongly to wet and dynamic wound surfaces, is capable of delivering antimicrobials, and supports cell migration and proliferation. This technology has the potential to address an unmet clinical need in wound healing.</p>","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 8","pages":"2795–2803"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Pharmacology and Translational Science","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsptsci.5c00341","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Chronic wounds affect millions worldwide and lead to pain, infection, and impaired quality of life. Current wound sealing technologies for chronic wound care remain largely palliative, with poor adhesion, weak mechanical properties, and limited ability to deliver therapeutics. Emerging technologies, including autologous blood products, growth factor-enhanced scaffolds, and artificial skin, although clinically successful, are limited from widespread adoption by the high cost of production and challenging clinical workflow. Here, we present a tough adhesive-elastomer wound care technology that is mechanically robust to approximate wound edges, can adhere strongly to wet and dynamic wound surfaces, is capable of delivering antimicrobials, and supports cell migration and proliferation. This technology has the potential to address an unmet clinical need in wound healing.
期刊介绍：
ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action, and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest to the journal. Nonetheless, all innovative and impactful research that has an articulated translational relevance will be considered.
ACS Pharmacology & Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition.
Authors are encouraged to use the pre-submission inquiry mechanism to ensure relevance and appropriateness of research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
