Sola Lee, Suk Kyun Hong, Ja Min Byun, Su Young Hong, Jae-Yoon Kim, Jiyoung Kim, Jeong-Moo Lee, Youngil Koh, YoungRok Choi, Dong-Yeop Shin, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
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引用次数: 0
Abstract
Background: Donor thrombophilia poses risks to both donors and recipients. To address donor safety without unnecessarily decreasing the donor pool, we aimed to determine the incidence of protein C (PC) or protein S (PS) deficiency among living liver donor candidates and propose a decision-making algorithm for donation.
Methods: We retrospectively reviewed 1421 living donor candidates who underwent primary donor evaluation at a single center between January 2017 and February 2022. Donors with PC or PS deficiency were divided into severe (< 40%), moderate (40%-49%), and mild (50%-59%) deficiencies and near-normal (> 60%) groups based on functional activity levels. Demographic and clinical data, including genetic mutation testing, donation status, and postoperative outcomes of both donors and recipients, were analyzed.
Results: The incidence of PC and PS deficiency after the repeat testing was 0.4% (n = 6) and 1.7% (n = 24), respectively. One donor with severe PS deficiency had a PROS1 mutation, and two donors (one from the near-normal group and one from the mild group) had PROC mutations. None of the 16 donors experienced any thrombotic complications. Three recipients experienced thrombotic complications that were not directly associated with donor thrombophilia.
Conclusion: The incidences of PC and PS deficiencies among liver donors are significant and should not be overlooked. Each center should consider geographic and ethnic variations when establishing efficient thrombophilia evaluation protocols to ensure donor safety.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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