Dasom Noh, Sunyoung Kwon, Woo Hyun Cho, Jin Gu Lee, Song Yee Kim, Samina Park, Kyeongman Jeon, Hye Ju Yeo
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引用次数: 0
Abstract
Background: In regions with limited donor availability, optimizing efficiency in lung transplant decision-making is crucial. Preoperative prediction of 1-year graft failure can enhance candidate selection and clinical decision-making.
Methods: We utilized data from the Korean Organ Transplantation Registry to develop and validate a deep learning-based model for predicting 1-year graft failure after lung transplantation. A total of 240 cases were analyzed using 5-fold cross-validation. Among 25 preoperative factors associated with 1-year graft failure, we selected the top 9 variables with coefficients ≥ 0.25 for model development.
Results: Of the 240 lung transplant recipients, 55 (22.92%) developed graft failure within 1 year, while 185 survived. The final predictive model incorporated nine key pretransplant factors: age, bronchiolitis obliterans syndrome after hematopoietic cell transplantation, pretransplant bacteremia, bronchiectasis, creatinine, diabetes, positive human leukocyte antigen crossmatch, panel reactive antibody 1 peak mean fluorescence intensity, and pretransplant steroid use. The multilayer perceptron model demonstrated strong predictive performance, achieving an area under the curve of 0.780 and an accuracy of 0.733.
Conclusions: Our machine learning-based model effectively predicts 1-year graft failure in lung transplant recipients using a minimal set of pretransplant variables. Further validation is needed to confirm its clinical applicability.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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