{"title":"A review on coordination and biological properties of selenosemicarbazone.","authors":"Vins Daniel, Vipin Singh, Prabal Gupta, Anandaram Sreekanth","doi":"10.1016/j.jinorgbio.2025.113020","DOIUrl":null,"url":null,"abstract":"<p><p>The review highlights the synthesis, coordination behavior, and extensive biological activities of selenosemicarbazones and their metal complexes. Over 110 selenosemicarbazone ligands coordinated with metals such as Cu, Ni, Zn, Pt, and Pd are discussed, showcasing significant structural diversity. These compounds uniquely combine the pharmacophoric semicarbazone moiety with selenium, a redox-active trace element, resulting in enhanced stability, reactivity, and biological performance. Coordinated metal complexes demonstrate potent antibacterial, anticancer, antioxidant, and antiparasitic activities. Mechanistic insights include reactive oxygen species (ROS) generation, metalloenzyme inhibition, and DNA binding. Recent developments in structure-activity relationships and therapeutic targeting are emphasized.</p>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"113020"},"PeriodicalIF":3.2000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jinorgbio.2025.113020","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The review highlights the synthesis, coordination behavior, and extensive biological activities of selenosemicarbazones and their metal complexes. Over 110 selenosemicarbazone ligands coordinated with metals such as Cu, Ni, Zn, Pt, and Pd are discussed, showcasing significant structural diversity. These compounds uniquely combine the pharmacophoric semicarbazone moiety with selenium, a redox-active trace element, resulting in enhanced stability, reactivity, and biological performance. Coordinated metal complexes demonstrate potent antibacterial, anticancer, antioxidant, and antiparasitic activities. Mechanistic insights include reactive oxygen species (ROS) generation, metalloenzyme inhibition, and DNA binding. Recent developments in structure-activity relationships and therapeutic targeting are emphasized.
期刊介绍：
The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.
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