Adverse drug reactions following SARS-CoV-2 vaccination of 3805 healthcare workers cause substantial sick-leave and are correlated to vaccine regimen, age, sex and serological response.

IF 3.5
Vaccine Pub Date : 2025-08-30 Epub Date: 2025-08-06 DOI:10.1016/j.vaccine.2025.127553
Anna-Karin Lidström, Bo Albinsson, Fredrik Sund, Johan Lindbäck, Florence van Hunsel, Tove Fall, Gabriel Westman
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Abstract

Background: Although SARS-CoV-2 vaccination was a critical component to mitigate impact of the pandemic, it also brought specific challenges related to adverse drug reactions (ADRs) when large cohorts of healthcare workers were vaccinated.

Methods and findings: This study reports solicited ADRs and IgG anti-SARS-CoV-2 levels from 3805 healthcare workers in Sweden following primary immunization during 2021. Differences in systemic reactions at a level where study participants needed sick-leave or rescheduling of work shifts differed substantially between vaccine regimens, ranging from 12 % (Comirnaty) to 48 % (heterologous vaccination with Vaxzevria/Spikevax). Multivariable linear regression showed that the anti-S IgG response was dependent on vaccine label and that higher age and increased time from vaccination significantly correlated with lower antibody titers. Multivariable logistic regression models describing the risk for each ADR category in relation to vaccine label, age, sex, anti-S IgG levels post vaccination and time from vaccination showed vaccine label-dependent statistically significant differences in adjusted odds ratios for wide range of ADR categories, as high as OR 10 (95 % CI 7.6-13.5) for fever and chills when comparing Vaxzevria to Comirnaty. Among the mRNA vaccines, use of Spikevax (compared to Comirnaty) correlated with a statistically significant 1.3 to 3.5-fold increase in adjusted ORs for several ADR categories.

Conclusions: Based on a large cohort of health workers, our study confirms that adverse reactions after COVID-19 vaccination can lead to a substantial amount of missed work shifts, potentially causing organizational-level disturbances in staffing. There are significant differences in ADR frequencies related to vaccine type, age and sex, at overall levels not observed for other commonly used vaccines for adults.

3805名医护人员接种SARS-CoV-2疫苗后药物不良反应导致大量病假,并与疫苗接种方案、年龄、性别和血清学反应相关。
背景:尽管SARS-CoV-2疫苗接种是减轻大流行影响的关键组成部分,但当大量卫生保健工作者接种疫苗时,它也带来了与药物不良反应(adr)相关的具体挑战。方法和结果:本研究报告征求了瑞典3805名卫生保健工作者在2021年进行初级免疫后的adr和IgG抗sars - cov -2水平。在研究参与者需要病假或重新安排工作轮班的水平上,系统反应的差异在疫苗方案之间存在很大差异,从12% (Comirnaty)到48% (Vaxzevria/Spikevax异种疫苗接种)。多变量线性回归显示,抗s IgG应答依赖于疫苗标签,年龄越大、接种时间越长,抗体滴度越低。多变量logistic回归模型描述了与疫苗标签、年龄、性别、接种后抗s IgG水平和接种时间相关的每个ADR类别的风险,结果显示,在广泛的ADR类别中,疫苗标签相关的调整优势比存在统计学显著差异,当将Vaxzevria与Comirnaty进行比较时,发烧和发冷的优势比高达10 (95% CI 7.6-13.5)。在mRNA疫苗中,Spikevax的使用(与Comirnaty相比)与几种ADR类别调整后的or增加1.3至3.5倍相关,具有统计学意义。结论:基于一大批卫生工作者,我们的研究证实,COVID-19疫苗接种后的不良反应可能导致大量缺勤,可能导致组织层面的人员配置紊乱。与疫苗类型、年龄和性别相关的不良反应频率存在显著差异,但在其他成人常用疫苗中未观察到总体水平差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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