4D flow MRI of aortic blood flow parameters in healthy volunteers: Sex- and age-specific analysis.

IF 2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Magnetic resonance imaging Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI:10.1016/j.mri.2025.110482
Gyu-Han Lee, Hojin Ha, Kyung Jin Park, Hyun Jung Koo, June-Goo Lee, Hyun Seo Lee, Jong Eun Lee, Dong Hyun Yang, Dae-Hee Kim
{"title":"4D flow MRI of aortic blood flow parameters in healthy volunteers: Sex- and age-specific analysis.","authors":"Gyu-Han Lee, Hojin Ha, Kyung Jin Park, Hyun Jung Koo, June-Goo Lee, Hyun Seo Lee, Jong Eun Lee, Dong Hyun Yang, Dae-Hee Kim","doi":"10.1016/j.mri.2025.110482","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Four-dimensional (4D) flow MRI enables comprehensive assessment of aortic hemodynamics, but normative values remain limited, especially for Asian populations. This study aimed to establish age- and sex-specific normative values for flow-related parameters in healthy Korean adults.</p><p><strong>Methods: </strong>Seventy-seven healthy volunteers (aged 20-79 years) underwent 4D flow MRI. Hemodynamic parameters-velocity, viscous energy loss, normalized vorticity, and helicity-were quantified in the ascending aorta (AAo), aortic arch (AoA), and descending aorta (DAo).</p><p><strong>Results: </strong>Significant sex differences were found for velocity in the AAo (p < 0.001) and viscous energy loss across all segments (p < 0.05), while normalized vorticity and helicity showed no sex-related differences. In viscous energy loss, males had higher values than females in the AAo (2.84 ± 1.05 vs 2.22 ± 0.60 mW, p = 0.017), AoA (0.74 ± 0.37 vs 0.42 ± 0.19 mW, p = 0.001), and DAo (4.78 ± 1.82 vs 3.32 ± 1.55 mW, p = 0.002). Most parameters demonstrated age-related declines, especially in the DAo. Strongest correlations with age were seen for velocity (r = -0.725, p < 0.001) and viscous energy loss (r = -0.745, p < 0.001). Positive helicity showed sex-specific aging trends, with the strongest correlations in the DAo for men and the AoA for women. Negative helicity showed the strongest correlation in the DAo in both sexes.</p><p><strong>Conclusions: </strong>This study established age- and sex-specific normative values for aortic hemodynamic parameters in healthy Korean adults using 4D flow MRI. While sex differences were limited, most flow parameters declined with age.</p>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":" ","pages":"110482"},"PeriodicalIF":2.0000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic resonance imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.mri.2025.110482","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: Four-dimensional (4D) flow MRI enables comprehensive assessment of aortic hemodynamics, but normative values remain limited, especially for Asian populations. This study aimed to establish age- and sex-specific normative values for flow-related parameters in healthy Korean adults.

Methods: Seventy-seven healthy volunteers (aged 20-79 years) underwent 4D flow MRI. Hemodynamic parameters-velocity, viscous energy loss, normalized vorticity, and helicity-were quantified in the ascending aorta (AAo), aortic arch (AoA), and descending aorta (DAo).

Results: Significant sex differences were found for velocity in the AAo (p < 0.001) and viscous energy loss across all segments (p < 0.05), while normalized vorticity and helicity showed no sex-related differences. In viscous energy loss, males had higher values than females in the AAo (2.84 ± 1.05 vs 2.22 ± 0.60 mW, p = 0.017), AoA (0.74 ± 0.37 vs 0.42 ± 0.19 mW, p = 0.001), and DAo (4.78 ± 1.82 vs 3.32 ± 1.55 mW, p = 0.002). Most parameters demonstrated age-related declines, especially in the DAo. Strongest correlations with age were seen for velocity (r = -0.725, p < 0.001) and viscous energy loss (r = -0.745, p < 0.001). Positive helicity showed sex-specific aging trends, with the strongest correlations in the DAo for men and the AoA for women. Negative helicity showed the strongest correlation in the DAo in both sexes.

Conclusions: This study established age- and sex-specific normative values for aortic hemodynamic parameters in healthy Korean adults using 4D flow MRI. While sex differences were limited, most flow parameters declined with age.

健康志愿者主动脉血流参数的4D血流MRI:性别和年龄特异性分析。
目的:四维(4D)血流MRI能够全面评估主动脉血流动力学,但规范值仍然有限,特别是对亚洲人群。本研究旨在建立年龄和性别特异性的韩国健康成人血流相关参数的规范性值。方法:77名健康志愿者(年龄20 ~ 79岁 )行4D血流MRI检查。对升主动脉(AAo)、主动脉弓(AoA)和降主动脉(DAo)的血流动力学参数——速度、粘性能量损失、归一化涡度和螺旋度进行量化。结论:本研究利用4D血流MRI建立了韩国健康成人主动脉血流动力学参数的年龄和性别特异性规范值。虽然性别差异有限,但大多数流量参数随着年龄的增长而下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信