Pyroptosis in gastric mucosal injury‑related diseases (Review).

IF 5.8 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

International journal of molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI:10.3892/ijmm.2025.5606

Bei Ji, Zhiyuan Ma, Shuhui Liu, Shun Yao, Kenichi Mizuno, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu

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引用次数: 0

Abstract

Gastric mucosal epithelial cells, immune cells and signaling molecules constitute the innate and adaptive immune systems of the gastric mucosa, working together to maintain its integrity. Once the balance is disrupted, gastric mucosal diseases may occur. Pyroptosis, as a unique inflammatory programmed cell death mechanism, participates in the dynamic balance between innate and adaptive immunity by identifying and responding to damage factors, and participating in the maturation and release process of inflammatory factors. Pyroptosis is involved in the association of gastric mucosal resistance with microbial invasion and endogenous damage. By releasing inflammatory factors, the immune environment of the gastric mucosa is reshaped, thereby affecting repair mechanisms and the specific direction of cell differentiation. The present review summarizes the important role of pyroptosis in focal and diffuse gastric mucosal injury. The review aims to provide a novel theoretical basis for the optimization of prevention strategies and treatment plans for current gastric mucosal diseases, and proposes a new option for the scientific management of these diseases.

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胃粘膜损伤相关疾病中的焦亡（综述）。

胃粘膜上皮细胞、免疫细胞和信号分子共同构成胃粘膜的先天免疫系统和适应性免疫系统，共同维护胃粘膜的完整性。一旦这种平衡被破坏，就可能发生胃粘膜疾病。焦亡是一种独特的炎性程序性细胞死亡机制，通过识别和响应损伤因子，参与先天免疫和适应性免疫的动态平衡，参与炎症因子的成熟和释放过程。胃粘膜耐药与微生物侵袭和内源性损伤有关。通过释放炎症因子，重塑胃粘膜的免疫环境，从而影响修复机制和细胞分化的特定方向。现就焦亡在局灶性和弥漫性胃粘膜损伤中的重要作用作一综述。本文旨在为当前胃粘膜疾病的预防策略和治疗方案的优化提供新的理论依据，并为这些疾病的科学管理提供新的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of molecular medicine 医学-医学：研究与实验

CiteScore

12.30

自引率

0.00%

发文量

124

审稿时长

3 months

期刊介绍： The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.