A new perspective for the diagnosis of pancreatic cancer: based on the understanding of extracellular vesicle proteins.

IF 3.6 3区医学 Q1 PATHOLOGY

Expert Review of Molecular Diagnostics Pub Date : 2025-10-01 Epub Date: 2025-08-11 DOI:10.1080/14737159.2025.2545968

Beihan Dong, Yaoyun Zhang, Tingyue Kang, Fujun Wang, Gang Su

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引用次数: 0

Abstract

Introduction: Pancreatic cancer (PC) has an insidious onset, limited treatment, and a poor prognosis. Extracellular vesicles (EVs) play a crucial role as a bridge for tumor microenvironment (TME)communication in tumorigenesis and development, especially EV proteins reflect the specificity of tumors. EVs serve as readily available biomarkers, and characterization of their protein profiles is expected to be a noninvasive molecular marker to improve the early diagnosis of Pancreatic ductal adenocarcinoma (PDAC) as well as potential therapeutic targets.

Areas covered: This review focuses on the mechanism by which all types of EV proteins are involved in PDAC. In addition, this review summarizes EV proteins as potential targets for the diagnosis and treatment of PDAC to fully understand the promise of EV proteins as liquid biopsies for PDAC.

Expert opinion: EVs in the humoral circulation represent an important part of liquid biopsy detection. EV protein profiling can be used as a liquid biopsy tool to detect cancer and distinguish cancer types. EV proteins have the characteristics of high specificity and sensitivity, but in view of the heterogeneity of tumors, EVs can be used as effective carriers for multiple candidate marker panels, and gradually realize personalized medicine for automated detection in the future.

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胰腺癌诊断的新视角：基于对细胞外囊泡蛋白的认识。

胰腺癌（PC）发病隐匿，治疗有限，预后差。细胞外囊泡（Extracellular vesicles, EVs）在肿瘤发生发展过程中作为肿瘤微环境（tumor microenvironment， TME）沟通的桥梁起着至关重要的作用，尤其是细胞外囊泡蛋白反映了肿瘤的特异性。EVs作为一种现成的生物标志物，其蛋白质谱的表征有望成为一种非侵入性分子标志物，以改善胰腺导管腺癌（PDAC）的早期诊断，并成为潜在的治疗靶点。涵盖领域：本文综述了各类EV蛋白参与PDAC的机制。此外，本文综述了EV蛋白作为PDAC诊断和治疗的潜在靶点，以充分了解EV蛋白作为PDAC液体活检的前景。专家意见：体液循环中的ev是液体活检检测的重要组成部分。EV蛋白谱分析可作为液体活检检测癌症和区分癌症类型的工具。EV蛋白具有高特异性和敏感性的特点，但鉴于肿瘤的异质性，未来EV可作为多种候选标志物面板的有效载体，逐步实现个性化医疗自动化检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.