Gut-Brain Dialogues in Fruit Fly (Drosophila melanogaster): How Peptide Hormones Bridge Metabolism, Longevity, and Behavioral Adaptation.

IF 2.5 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2025-08-06 DOI:10.2174/0113894501397622250801062050

Mengzhe Tian, Shushen Sun, Qinghao Meng, Jingyi Li, Xinyi Li, Suxia Ren, Zengyi Huang, Shaoshan Du, Yiwen Wang

{"title":"Gut-Brain Dialogues in Fruit Fly (Drosophila melanogaster): How Peptide Hormones Bridge Metabolism, Longevity, and Behavioral Adaptation.","authors":"Mengzhe Tian, Shushen Sun, Qinghao Meng, Jingyi Li, Xinyi Li, Suxia Ren, Zengyi Huang, Shaoshan Du, Yiwen Wang","doi":"10.2174/0113894501397622250801062050","DOIUrl":null,"url":null,"abstract":"Background: Gut-peptide hormones are crucial regulators of various physiological processes, including metabolism, digestion, behavior, and homeostasis. In Drosophila melanogaster, a widely used model organism, a diverse range of gut-peptide hormones governs gut-brain communication, influencing food intake, energy balance, circadian rhythms, stress responses, and aging.Objective: This review summarizes recent studies on gut-peptide hormones in D. melanogaster, focusing on their mechanisms of action, interactions with other signaling pathways, and their relevance to human orthologs.Methods: The PubMed database was searched for studies on gut-peptide hormones in D. melanogaster published in the past decade.Results: The functions of D. melanogaster gut-peptide hormones were reviewed, including DH31, Bursicon (Burs), Tachykinins (Tks), Hedgehog (Hh), Pigment-dispersing factor (PDF), Neuropeptide F (NPF), Short neuropeptide F (sNPF), Allatostatins (ASTs), CCHamides (CCHa), and Limostatin (Lst). These hormones regulate key physiological processes such as digestion, energy homeostasis, and metabolism through conserved pathways.Conclusion: Drosophila melanogaster gut-peptide hormones are fundamental regulators of health and disease. They are conducive to exploring conserved mechanisms for developing treatments against human metabolic and aging disorders.","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug targets","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113894501397622250801062050","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Gut-peptide hormones are crucial regulators of various physiological processes, including metabolism, digestion, behavior, and homeostasis. In Drosophila melanogaster, a widely used model organism, a diverse range of gut-peptide hormones governs gut-brain communication, influencing food intake, energy balance, circadian rhythms, stress responses, and aging.

Objective: This review summarizes recent studies on gut-peptide hormones in D. melanogaster, focusing on their mechanisms of action, interactions with other signaling pathways, and their relevance to human orthologs.

Methods: The PubMed database was searched for studies on gut-peptide hormones in D. melanogaster published in the past decade.

Results: The functions of D. melanogaster gut-peptide hormones were reviewed, including DH31, Bursicon (Burs), Tachykinins (Tks), Hedgehog (Hh), Pigment-dispersing factor (PDF), Neuropeptide F (NPF), Short neuropeptide F (sNPF), Allatostatins (ASTs), CCHamides (CCHa), and Limostatin (Lst). These hormones regulate key physiological processes such as digestion, energy homeostasis, and metabolism through conserved pathways.

Conclusion: Drosophila melanogaster gut-peptide hormones are fundamental regulators of health and disease. They are conducive to exploring conserved mechanisms for developing treatments against human metabolic and aging disorders.

查看原文本刊更多论文

果蝇（Drosophila melanogaster）的肠脑对话：肽激素如何桥接代谢、长寿和行为适应。

背景：肠肽激素是多种生理过程的重要调节因子，包括代谢、消化、行为和体内平衡。在黑腹果蝇（Drosophila melanogaster）这种被广泛应用的模式生物中，多种肠道肽激素控制着肠-脑通讯，影响食物摄入、能量平衡、昼夜节律、应激反应和衰老。目的：综述了黑腹龙肠肽激素的研究进展，重点介绍了它们的作用机制、与其他信号通路的相互作用以及它们与人类同源物的相关性。方法：检索PubMed数据库中近十年来发表的关于黑腹龙肠道肽激素的研究。结果：综述了黑胃d肠肽激素的功能，包括DH31、bursiicon （Burs）、Tachykinins （Tks）、Hedgehog （Hh）、色素分散因子（PDF）、神经肽F （NPF）、短神经肽F （sNPF）、Allatostatins （ast）、CCHamides （CCHa）和Limostatin （Lst）。这些激素通过保守的途径调节关键的生理过程，如消化、能量稳态和代谢。结论：黑腹果蝇肠肽激素是健康和疾病的重要调节因子。它们有助于探索治疗人类代谢和衰老疾病的保守机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.