Research advances of extracellular vesicles in lung diseases.

IF 3.2 4区 医学 Q3 CELL & TISSUE ENGINEERING
Cell Transplantation Pub Date : 2025-01-01 Epub Date: 2025-08-08 DOI:10.1177/09636897251362031
Jian Wang, Yaning Shi, Yuehan Su, Chaoyue Pang, Yimiao Yang, Weiwei Wang
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引用次数: 0

Abstract

The lung is a vital organ in the respiratory system, and there is a critical need to develop more effective methods for lung health management. Extracellular vesicles (EVs) play an important role in intercellular communication. They exhibit high bioavailability and low immunogenicity, making them essential in maintaining cellular homeostasis and in the prevention and treatment of numerous diseases. This review describes the diverse sources, isolation techniques, functions, and challenges associated with EVs, particularly exosomes. We highlight their significant role in the diagnosis and treatment of lung diseases, as well as their potential as drug delivery vehicles. By synthesizing recent advances in EVs research, this review aims to provide a theoretical foundation for future studies and clinical applications of EVs.

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肺疾病细胞外囊泡的研究进展。
肺是呼吸系统的重要器官,迫切需要开发更有效的肺健康管理方法。细胞外囊泡(EVs)在细胞间通讯中起着重要作用。它们表现出高生物利用度和低免疫原性,使它们在维持细胞稳态和预防和治疗许多疾病中必不可少。本文综述了与ev,特别是外泌体相关的各种来源、分离技术、功能和挑战。我们强调它们在肺部疾病的诊断和治疗中的重要作用,以及它们作为药物输送载体的潜力。本文综述了近年来电动汽车的研究进展,旨在为电动汽车的进一步研究和临床应用提供理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Transplantation
Cell Transplantation 生物-细胞与组织工程
CiteScore
6.00
自引率
3.00%
发文量
97
审稿时长
6 months
期刊介绍: Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.
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