Synthesis, structure, catalytic and cytotoxic activities of chlorido­(5-nitro­quinolin-8-olato-κ2N,O)(tri­cyclo­hexyl­phosphine-κP)platinum(II)

Abstract

In the title square-planar complex, the P atom of the tri­cyclo­hexyl­phosphine group coordinates to the metal atom in the trans position compared to the coordinating N atom. The complex shows significant catalytic ability and selectivity for hydro­silylation between phenyl­acetyl­ene and tri­ethyl­silane.

The title complex, [Pt(C₁₀H₅N₂O₃)Cl(C₁₈H₃₃P)], was synthesized by the reaction of [PtCl(C₁₀H₅N₂O₃)(η²-C₂H₄)] and PCy₃ at room temperature for 2 h with a yield of 80%. The deprotonated 5-nitro­quinoline-8-ol (C₁₀H₅N₂O₃⁻) anion coordinates to the metal atom in a bidentate mode via its N and O atoms with a N—Pt—O bite angle of 80.0 (3)°. The tri­cyclo­hexyl­phosphine P atom is in a trans position with respect to the N atom in the square-planar coordination environment of the metal atom. The packing features zigzag chains linked by C—H⋯O inter­actions and continuous channels occupied by disordered solvent mol­ecules, both running in the a-axis direction. The complex shows weak activity against four cancer cell lines with IC₅₀ values > 120 µM, but significant catalytic ability and selectivity for hydro­silylation between phenyl­acetyl­ene and tri­ethyl­silane.