Reticuline modulates astrocyte and microglial responses to enhance prognosis after traumatic brain injury.

IF 6.9 2区医学 Q1 CLINICAL NEUROLOGY

Neurotherapeutics Pub Date : 2025-08-05 DOI:10.1016/j.neurot.2025.e00709

Shuhui Xu, Jue Zhu, Jiajia Wen, Chenxing Wang, Xuanfeng Chen, Weiquan Liao, Zhichao Lu, Ziheng Wang, Peipei Gong

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引用次数: 0

Abstract

Traumatic brain injury (TBI) poses a serious threat to public health due to its high disability and mortality rates. Therefore, it is crucial to explore effective therapeutic strategies. Studies have shown that reticuline may exert a cardioprotective effect by blocking the JAK-STAT signaling pathway, but its effect in TBI has not been explored. Therefore, this study aimed to evaluate the potential clinical value of reticuline after TBI and its impact on the inflammatory quiescent state. This study assessed the therapeutic effect of reticuline administered intraperitoneally using the controlled cortical impact (CCI) model in adult rats. In addition, to clarify the mechanism of action of reticuline, we used Colivelin, a STAT3 agonist, to restore the function of related signal pathways and explore its intervention effect. The study showed that reticuline inhibited neuroinflammation and promoted neurological function recovery after TBI by regulating the JAK-STAT signaling pathway, reducing the toxic response of astrocytes and microglia while retaining its neuroprotective effect. In summary, this study reveals that reticuline may promote neural repair after TBI through a JAK-STAT-dependent anti-inflammatory effect. Our findings further expand its potential application value in brain injury treatment and provide new ideas for intervention strategies for TBI.

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Reticuline调节星形胶质细胞和小胶质细胞的反应，提高创伤性脑损伤后的预后。

外伤性脑损伤因其高致残率和高死亡率对公众健康构成严重威胁。因此，探索有效的治疗策略至关重要。研究表明，reticuline可能通过阻断JAK-STAT信号通路发挥心脏保护作用，但其在TBI中的作用尚未探讨。因此，本研究旨在评估网状碱在脑外伤后的潜在临床价值及其对炎症静止状态的影响。本研究采用控制皮质冲击（CCI）模型，对成年大鼠腹腔给药网状碱的治疗效果进行了评价。此外，为了明确reticuline的作用机制，我们使用STAT3激动剂Colivelin恢复相关信号通路的功能，并探讨其干预作用。研究表明，网状碱通过调节JAK-STAT信号通路，抑制脑外伤后神经炎症，促进神经功能恢复，减少星形胶质细胞和小胶质细胞的毒性反应，同时保持其神经保护作用。综上所述，本研究表明网状碱可能通过jak - stat依赖的抗炎作用促进TBI后的神经修复。本研究结果进一步拓展了其在脑损伤治疗中的潜在应用价值，并为TBI的干预策略提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotherapeutics 医学-神经科学

CiteScore

11.00

自引率

3.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.