Supersaturated Oxygen Delivery & Acute MI: Current Evidence, Practical Issues, and Future Research.

IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Adhvithi Pingili, Mounika Reddy Vadiyala, Maneeth Mylavarapu, Muhammad Bilal, Narayana Varalakshmi Akula, Mallareddy Banala, Neelima Katukuri
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引用次数: 0

Abstract

Introduction: Acute myocardial infarction is a significant global health issue, with a high mortality rate. Early intervention, specifically coronary angiography, has been shown to improve patient outcomes significantly. Recent technological advances have introduced novel therapeutic interventions like Supersaturated Oxygen (SSO2) Therapy, which promises enhanced recovery post-ischemia. To evaluate the efficacy and potential benefits of SSO2 therapy in improving post-ischemic outcomes, including left ventricular function, myocardial scarring, and overall cardiac morphology.

Methods: This review synthesizes findings from early clinical trials and pre-clinical animal studies focusing on the application of SSO2. The therapy involves delivering oxygen at ten times the normal level directly to the infarcted artery to facilitate high oxygen diffusion before restoring downstream flow.

Results: Pre-clinical studies demonstrate that SSO2 therapy enhances Left ventricular ejection fraction (LVEF), increases mean arterial PaO2, reduces myocardial apoptosis, and decreases myocardial scarring and infarct sizes. Clinical trials, including the Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT I and AMIHOT II), have shown improvements in echocardiographic regional wall motion and have helped in preventing myocardial dilatation and remodeling.

Conclusion: SSO2 therapy presents a promising advance in the treatment of myocardial infarction. While early results are favorable, indicating significant improvements in cardiac function and tissue preservation, long-term follow-up studies are necessary to determine the impact on mortality rates, recurrence of ischemic events, and healthcare resource utilization.

过饱和氧输送与急性心肌梗死:目前的证据,实际问题和未来的研究。
急性心肌梗死是一个重要的全球性健康问题,死亡率很高。早期干预,特别是冠状动脉造影,已被证明可以显著改善患者的预后。最近的技术进步带来了新的治疗干预措施,如过饱和氧(SSO2)治疗,有望增强缺血后的恢复。评估SSO2治疗在改善缺血后预后方面的疗效和潜在益处,包括左心室功能、心肌瘢痕形成和整体心脏形态。方法:本文以SSO2的应用为重点,综合早期临床试验和临床前动物研究结果。该疗法包括在恢复下游血流之前,向梗死动脉直接输送10倍于正常水平的氧气,以促进高氧扩散。结果:临床前研究表明,SSO2治疗可提高左室射血分数(LVEF),增加平均动脉PaO2,减少心肌凋亡,减少心肌瘢痕形成和梗死面积。临床试验,包括急性心肌梗死高氧治疗(AMIHOT I和AMIHOT II),显示超声心动图区域壁运动的改善,并有助于防止心肌扩张和重构。结论:SSO2治疗心肌梗死具有广阔的应用前景。虽然早期结果是有利的,表明心功能和组织保存有显著改善,但需要长期随访研究来确定对死亡率、缺血性事件复发和医疗资源利用的影响。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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