Synthesis of pisiferic acid analogues and their anti-adipogenic effect in 3T3-L1 adipocytes.

IF 2.2 4区 医学 Q3 CHEMISTRY, MEDICINAL
Bioorganic & Medicinal Chemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-08-07 DOI:10.1016/j.bmcl.2025.130354
Ayako Oshika, Sayumi Ono, Haruka Iwano, Manami Toda, Risa Obayashi, Yuna Takagi, Mako Higashitani, Satomi Fukuoka, Miduki Furukawa, Karen Yagami, Rena Okamura, Natsumi Futoi, Hiroki Yoshioka, Reiko Yano, Koji Yoshida, Hyun-Sun Park, Tomoyo Hasuda, Yukio Hitotsuyanagi, Koichi Takeya, Tomohiro Yamaguchi, Yutaka Aoyagi
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引用次数: 0

Abstract

12-O-alkyl, acyl, and phenylcarbamoyl, and 11-bromo-7-oxo analogues were prepared from pisiferic acid from Chamaecyparis pisifera, and evaluated anti-adipogenic activity. Among them, pisiferic acid and methyl 12-O-phenylcarbamoylpisiferic acid methyl ester showed relatively high anti-adipogenic effect in 3T3-L1 adipocytes and should be thought to be potential candidates for anti-obesity drug.

三烯二酸类似物的合成及其对3T3-L1脂肪细胞的抗脂肪生成作用。
以松香豆酸为原料制备了12- o-烷基、酰基、苯基氨基甲酰和11-溴-7-氧类似物,并对其抗脂肪活性进行了评价。其中,pisiferic酸和甲基12- o -苯基氨基甲酰pisiferic酸甲酯在3T3-L1脂肪细胞中表现出较高的抗脂肪作用,应被认为是抗肥胖药物的潜在候选者。
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来源期刊
CiteScore
5.70
自引率
3.70%
发文量
463
审稿时长
27 days
期刊介绍: Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.
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