Hyperglycemia, diabetes, and de novo diabetes in patients hospitalized in intensive care units for COVID-19 in Colombia: Results from a longitudinal cohort study.

IF 1.7 Q4 CRITICAL CARE MEDICINE
Journal of Critical Care Medicine Pub Date : 2025-07-31 eCollection Date: 2025-07-01 DOI:10.2478/jccm-2025-0026
John Jaime Sprockel, Ana Maria Perez, Maria Camila Chamorro, Jose Alejandro Vergel, Ximena Espinosa, Juan Carlos Vargas, Carlos Angarita, Jhon Edinson Parra
{"title":"Hyperglycemia, diabetes, and de novo diabetes in patients hospitalized in intensive care units for COVID-19 in Colombia: Results from a longitudinal cohort study.","authors":"John Jaime Sprockel, Ana Maria Perez, Maria Camila Chamorro, Jose Alejandro Vergel, Ximena Espinosa, Juan Carlos Vargas, Carlos Angarita, Jhon Edinson Parra","doi":"10.2478/jccm-2025-0026","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Hyperglycemia and diabetes have been identified as risk factors for severe COVID-19 and death, with a high rate of reported de novo diabetes. We evaluated their incidence and relationship with adverse outcomes in critically ill COVID-19 patients.</p><p><strong>Methods: </strong>Prospective single-center longitudinal cohort study in adults hospitalized in intensive care units for confirmed COVID-19. ROC curves for serum glucose and glycated hemoglobin were plotted in relation to 60-day mortality. A Cox proportional hazards model was used to assess the association of diabetes and de novo diabetes with 60-day mortality.</p><p><strong>Results: </strong>547 patients were included, with a mean age of 59.8 years; 133 (24.3%) had a history of diabetes, and 67 (12.2%) had de novo diabetes. At 60 days, 317 (57.9%) had died. For mortality, the AUC for glucose at admission was 0.55 (95% CI: 0.48 - 0.62) and 0.51 (95% CI: 0.41 - 0.62) for glycated hemoglobin. In the Cox model, diabetes had an HR of 0.888 (95% CI: 0.695 - 1.135, p: 0.344), history of DM had an HR of 0.881 (95% CI: 0.668 - 1.163, p: 0.371), and de novo diabetes had an HR of 0.963 (95% CI: 0.672 - 1.378, p: 0.835).</p><p><strong>Conclusion: </strong>There was a high incidence of de novo diabetes in patients hospitalized in intensive care for COVID-19. Neither hyperglycemia, history of diabetes, nor de novo diabetes were associated with the development of complications or 60-day mortality.</p>","PeriodicalId":44227,"journal":{"name":"Journal of Critical Care Medicine","volume":"11 3","pages":"257-264"},"PeriodicalIF":1.7000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321255/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Critical Care Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/jccm-2025-0026","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Hyperglycemia and diabetes have been identified as risk factors for severe COVID-19 and death, with a high rate of reported de novo diabetes. We evaluated their incidence and relationship with adverse outcomes in critically ill COVID-19 patients.

Methods: Prospective single-center longitudinal cohort study in adults hospitalized in intensive care units for confirmed COVID-19. ROC curves for serum glucose and glycated hemoglobin were plotted in relation to 60-day mortality. A Cox proportional hazards model was used to assess the association of diabetes and de novo diabetes with 60-day mortality.

Results: 547 patients were included, with a mean age of 59.8 years; 133 (24.3%) had a history of diabetes, and 67 (12.2%) had de novo diabetes. At 60 days, 317 (57.9%) had died. For mortality, the AUC for glucose at admission was 0.55 (95% CI: 0.48 - 0.62) and 0.51 (95% CI: 0.41 - 0.62) for glycated hemoglobin. In the Cox model, diabetes had an HR of 0.888 (95% CI: 0.695 - 1.135, p: 0.344), history of DM had an HR of 0.881 (95% CI: 0.668 - 1.163, p: 0.371), and de novo diabetes had an HR of 0.963 (95% CI: 0.672 - 1.378, p: 0.835).

Conclusion: There was a high incidence of de novo diabetes in patients hospitalized in intensive care for COVID-19. Neither hyperglycemia, history of diabetes, nor de novo diabetes were associated with the development of complications or 60-day mortality.

Abstract Image

Abstract Image

Abstract Image

哥伦比亚COVID-19重症监护病房住院患者的高血糖、糖尿病和新发糖尿病:一项纵向队列研究的结果
导语:高血糖和糖尿病已被确定为严重COVID-19和死亡的危险因素,新发糖尿病的报告率很高。我们评估了重症COVID-19患者的发病率及其与不良结局的关系。方法:对确诊COVID-19在重症监护病房住院的成人进行前瞻性单中心纵向队列研究。绘制与60天死亡率相关的血清葡萄糖和糖化血红蛋白的ROC曲线。采用Cox比例风险模型评估糖尿病和新生糖尿病与60天死亡率的关系。结果:纳入547例患者,平均年龄59.8岁;有糖尿病史133例(24.3%),新发糖尿病67例(12.2%)。60天死亡317例(57.9%)。对于死亡率,入院时葡萄糖的AUC为0.55 (95% CI: 0.48 - 0.62),糖化血红蛋白的AUC为0.51 (95% CI: 0.41 - 0.62)。在Cox模型中,糖尿病的风险比为0.888 (95% CI: 0.695 - 1.135, p: 0.344),糖尿病病史的风险比为0.881 (95% CI: 0.668 - 1.163, p: 0.371),新发糖尿病的风险比为0.963 (95% CI: 0.672 - 1.378, p: 0.835)。结论:新型冠状病毒肺炎重症监护住院患者新发糖尿病发生率较高。高血糖、糖尿病史和新发糖尿病均与并发症的发生或60天死亡率无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Critical Care Medicine
Journal of Critical Care Medicine CRITICAL CARE MEDICINE-
CiteScore
2.00
自引率
9.10%
发文量
21
审稿时长
11 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信