{"title":"Assessing Global Nursing Interventions in Reducing Hospital-Acquired Infections: A Meta-Analysis.","authors":"Fuping Ye, Lingfei Ma","doi":"10.18502/ijph.v54i5.18627","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hospital-acquired infections (HAIs) raise worldwide morbidity, death, and healthcare expenditures. Preventing and managing HAIs requires nursing interventions such hand hygiene, personal protective equipment (PPE) usage, environmental cleaning, and antimicrobial stewardship. This meta-analysis examined how nursing interventions reduced HAIs in different hospital settings.</p><p><strong>Methods: </strong>A complete PubMed, Scopus, and Web of Science search was undertaken for January 2000-December 2023 research. Studies on HAI-reducing nursing interventions were included. Study quality was evaluated using the Cochrane Risk of Bias Tool and Newcastle-Ottawa Scale. The random-effects model was used to construct pooled risk ratios (RRs) with 95% CIs in meta-analysis. We also performed subgroup, sensitivity, and publication bias analyses.</p><p><strong>Results: </strong>Fourteen trials with 2540 individuals were included. In the pooled study, nursing interventions significantly reduced HAI incidence (RR = 0.42, 95% CI: 0.35-0.50, <i>P</i> < 0.001). Subgroup analysis indicated that hand hygiene, PPE usage, environmental cleaning, and antimicrobial stewardship reduced HAIs. Sensitivity analysis verified these results' reliability. Egger's test showed no publication bias (<i>P</i> = 0.78). Over time, cumulative meta-analysis showed constant effect sizes.</p><p><strong>Conclusion: </strong>Nursing interventions significantly reduce HAIs. Hand hygiene, PPE, environmental cleaning, and antimicrobial stewardship are essential to infection control. Healthcare institutions should prioritise these actions and resolve compliance hurdles to enhance patient outcomes and minimise HAIs. Research is needed to explore innovative approaches and identify factors influencing compliance.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"54 5","pages":"915-927"},"PeriodicalIF":1.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319439/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijph.v54i5.18627","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Hospital-acquired infections (HAIs) raise worldwide morbidity, death, and healthcare expenditures. Preventing and managing HAIs requires nursing interventions such hand hygiene, personal protective equipment (PPE) usage, environmental cleaning, and antimicrobial stewardship. This meta-analysis examined how nursing interventions reduced HAIs in different hospital settings.
Methods: A complete PubMed, Scopus, and Web of Science search was undertaken for January 2000-December 2023 research. Studies on HAI-reducing nursing interventions were included. Study quality was evaluated using the Cochrane Risk of Bias Tool and Newcastle-Ottawa Scale. The random-effects model was used to construct pooled risk ratios (RRs) with 95% CIs in meta-analysis. We also performed subgroup, sensitivity, and publication bias analyses.
Results: Fourteen trials with 2540 individuals were included. In the pooled study, nursing interventions significantly reduced HAI incidence (RR = 0.42, 95% CI: 0.35-0.50, P < 0.001). Subgroup analysis indicated that hand hygiene, PPE usage, environmental cleaning, and antimicrobial stewardship reduced HAIs. Sensitivity analysis verified these results' reliability. Egger's test showed no publication bias (P = 0.78). Over time, cumulative meta-analysis showed constant effect sizes.
Conclusion: Nursing interventions significantly reduce HAIs. Hand hygiene, PPE, environmental cleaning, and antimicrobial stewardship are essential to infection control. Healthcare institutions should prioritise these actions and resolve compliance hurdles to enhance patient outcomes and minimise HAIs. Research is needed to explore innovative approaches and identify factors influencing compliance.
期刊介绍：
Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.
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