{"title":"Post-transcriptional control during T4 infection.","authors":"Jinshil Kim, Bokyung Son","doi":"10.1128/ecosalplus.esp-0009-2025","DOIUrl":null,"url":null,"abstract":"<p><p>Bacteriophage T4 has provided a model system for understanding post-transcriptional regulation in prokaryotes. This review summarizes several mechanisms of RNA processing and translational control in T4 infection, focusing on the coordinated actions of phage and host RNases. Key regulators such as RNase E, RegB, and tRNA-processing enzymes are discussed, along with the roles of RNA secondary structures and the translational repressors gp32, gp43, and RegA. In addition, we review recent studies that show how the host's antiphage toxin-antitoxin defense systems target T4 mRNAs as well as counter-strategies by the phage. Together, these components help to ensure temporal precision and efficiency of phage gene expression during phage infection.</p>","PeriodicalId":11500,"journal":{"name":"EcoSal Plus","volume":" ","pages":"eesp00092025"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"EcoSal Plus","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/ecosalplus.esp-0009-2025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Bacteriophage T4 has provided a model system for understanding post-transcriptional regulation in prokaryotes. This review summarizes several mechanisms of RNA processing and translational control in T4 infection, focusing on the coordinated actions of phage and host RNases. Key regulators such as RNase E, RegB, and tRNA-processing enzymes are discussed, along with the roles of RNA secondary structures and the translational repressors gp32, gp43, and RegA. In addition, we review recent studies that show how the host's antiphage toxin-antitoxin defense systems target T4 mRNAs as well as counter-strategies by the phage. Together, these components help to ensure temporal precision and efficiency of phage gene expression during phage infection.
EcoSal PlusImmunology and Microbiology-Microbiology
CiteScore
12.20
自引率
0.00%
发文量
4
期刊介绍：
EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.
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