A Multicenter Randomized Controlled Trial of Meditation and Health Education in the Prevention of Cardiometabolic Disease in Black Women.

Journal of women's health (2002) Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI:10.1177/15409996251364663
Carolyn Gaylord-King, Charlie L Harris, Shichen Xu, John W Salerno, Kenneth G Walton, C Noel Bairey-Merz, Sanford Nidich, Robert H Schneider
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Abstract

Introduction: Black American women suffer from disproportionately high rates of cardiovascular disease (CVD). This disparity may be related to psychosocial stress and cardiometabolic risk factors. Therefore, the objective of this trial was to evaluate the efficacy of a stress-reducing meditation technique compared with health education on cardiometabolic disease endpoints in high CVD risk Black women. Methods: The participants were Black women with documented CVD or with high CVD risk scores. They were randomly allocated to either Transcendental Meditation (TM) or health education (HE) for one year. Cardiometabolic endpoints were tested at baseline and after 12 months. Outcomes were carotid intima-media thickness (cIMT), hemoglobin A1c (HbA1c), insulin resistance (homeostatic model assessment [HOMA] IR), blood lipids, blood pressure (BP), weight, and physical activity. Results: A total of 201 participants enrolled (average age 64.6). After 1 year, the TM and HE groups showed decreases in cIMT with no significant difference between groups. In a post hoc exploratory analysis, both TM and HE demonstrated reductions in cIMT compared with historical controls (p = 0.006). The TM group showed reductions in HbA1c (p = 0.0030) and HOMA IR compared with HE (p = 0.03) and increased HDL (p = 0.01). Systolic and diastolic BP decreased in both groups without significant difference. In the overweight/obese subgroup, there was nearly 5% weight loss in the TM compared to the HE group. Discussion: In high-risk Black women, TM or HE participation was associated with prevention of progression of cIMT, while the TM group showed improvements in cardiometabolic disease endpoints of HbA1c, IR, and HDL cholesterol and weight loss in overweight/obese participants.

冥想和健康教育在黑人妇女预防心脏代谢疾病中的多中心随机对照试验
美国黑人妇女患心血管疾病(CVD)的比例高得不成比例。这种差异可能与心理社会压力和心脏代谢危险因素有关。因此,本试验的目的是评估减压冥想技术与健康教育在心血管疾病高风险黑人女性心血管代谢疾病终点的疗效。方法:参与者是有CVD记录或CVD风险评分较高的黑人女性。他们被随机分配参加为期一年的超觉冥想(TM)或健康教育(HE)。在基线和12个月后检测心脏代谢终点。结果是颈动脉内膜-中膜厚度(cIMT)、血红蛋白A1c (HbA1c)、胰岛素抵抗(稳态模型评估[HOMA] IR)、血脂、血压(BP)、体重和身体活动。结果:共有201名参与者入组,平均年龄64.6岁。1年后,TM组和HE组的cIMT下降,组间无显著差异。在事后的探索性分析中,与历史对照组相比,TM和HE均显示cIMT降低(p = 0.006)。与HE组相比,TM组HbA1c (p = 0.0030)和HOMA IR降低(p = 0.03), HDL升高(p = 0.01)。两组患者收缩压和舒张压均降低,差异无统计学意义。在超重/肥胖亚组中,与HE组相比,TM组的体重减轻了近5%。讨论:在高危黑人女性中,TM或HE参与与cIMT进展的预防相关,而TM组在HbA1c、IR和HDL胆固醇的心脏代谢疾病终点和超重/肥胖参与者的体重减轻方面表现出改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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