Trends and disparities in hypertension-related mortality among adults with obesity in the United States from 2000–2023

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences Pub Date : 2025-08-05 DOI:10.1016/j.amjms.2025.08.003

Shaheer Qureshi MBBS, Taimor Mohammed Khan MBBS, Hussain Salim MBBS, Muhammad Salik Uddin MBBS, Zahra Imran MBBS, Dua Ali MBBS, Maryam Sajid MBBS, Hibah Siddiqui MBBS, Saad Ahmed Waqas MBBS

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引用次数: 0

Abstract

Introduction

Obesity and hypertension are major public health concerns in the United States (US), significantly contributing to mortality. Despite their well-established association, long-term trends and demographic disparities in hypertension-related mortality among individuals with obesity remain underexamined. This study evaluates these trends, focusing on variations by sex, race, geographic region, and urbanization level.

Methods

Mortality data from individuals aged ≥25 years with obesity (ICD-10-CM: E66) and hypertension (ICD-10-CM: I10–I15) as underlying or contributing causes of death were extracted from the CDC WONDER database (2000–2023). Age-adjusted mortality rates (AAMRs) were calculated across demographic subgroups. Joinpoint regression estimated the average annual percentage change (AAPC). Sensitivity analyses assessed trends when hypertension was the primary cause of death.

Results

Between 2000 and 2023, 410,416 hypertension-related deaths occurred in individuals with obesity. AAMR increased from 2.58 per 100,000 in 2000 to 13.23 in 2023 (AAPC: +7.16 %, 95 % CI: 6.66–8.52, p < 0.001). Males had higher AAMRs than females, with NH Black individuals experiencing the highest mortality rates. Nonmetropolitan areas and Southern US had significantly higher AAMRs. Mortality spiked between 2019 and 2021, likely due to COVID-19, before declining in 2023.

Discussion

The rising hypertension-related mortality in individuals with obesity highlights the growing burden of cardiometabolic disease. The COVID-19 pandemic exacerbated these trends, but recent declines suggest potential benefits from improved public health measures.

Conclusions

Hypertension-related mortality in individuals with obesity has risen substantially, with significant disparities by sex, race, and geography. Targeted interventions are needed to address these disparities and reduce obesity-related hypertension mortality.

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2000-2023年美国肥胖成人高血压相关死亡率的趋势和差异

在美国，肥胖和高血压是主要的公共卫生问题，是导致死亡率的重要因素。尽管两者之间存在着明确的关联，但肥胖症患者高血压相关死亡率的长期趋势和人口差异仍未得到充分研究。本研究评估了这些趋势，重点关注性别、种族、地理区域和城市化水平的变化。方法：从CDC WONDER数据库（2000-2023）中提取年龄≥25岁的肥胖（ICD-10-CM: E66）和高血压（ICD-10-CM: I10-I15）作为潜在或促成死亡原因的死亡率数据。计算各人口亚组的年龄调整死亡率（AAMRs）。接合点回归估计年百分比变化（APC）。敏感性分析评估了当高血压是主要死亡原因时的趋势。结果：2000年至2023年间，410,416例高血压相关死亡发生在肥胖人群中。AAMR从2000年的2.58 / 10万增加到2023年的13.23 / 10万（AAPC: +7.16%, 95% CI: 6.66-8.52, p < 0.001）。男性的aamr高于女性，NH黑人个体的死亡率最高。非大都市地区和美国南部的aamr明显更高。2019年至2021年期间，死亡率飙升，可能是由于COVID-19，然后在2023年下降。讨论：肥胖患者高血压相关死亡率的上升凸显了心脏代谢疾病日益加重的负担。COVID-19大流行加剧了这些趋势，但最近的下降表明，改善公共卫生措施可能带来好处。结论：肥胖患者高血压相关死亡率大幅上升，性别、种族和地理差异显著。需要有针对性的干预措施来解决这些差异并降低与肥胖相关的高血压死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.