Effects of DNA methylation and polygenic scores on self-reported suicidal ideation in psychoses: no evidence of epigenetic basis of polygenic risk.

IF 1.4 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI:10.1097/YPG.0000000000000398

George Nader, Matisse Ducharme, Philip Gerretsen, Corinne Fischer, Ariel Graff, Vincenzo De Luca

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引用次数: 0

Abstract

Introduction: Schizophrenia is a significant clinical problem. Unfortunately, there are currently no biomarkers available for accurately identifying patients with schizophrenia who may be vulnerable to suicide. Because genetic and environmental factors play a role in suicide, we attempted to determine the role of DNA methylation and polygenic risk scores in the relationship to suicidal ideation.

Methods: Using a cross-sectional study design, 98 participants with schizophrenia spectrum disorders were interviewed, and suicidal ideation was assessed using the Beck Scale for suicidal ideation, and whole blood was collected for methylation analysis.

Results: Our analysis showed a correlation between cg21813303 methylation and suicidal ideation, but this association did not reach genome-wide significance. The polygenic risk scores for suicidality were not associated with schizophrenia severity, and no biological relationship was found between DNA methylation and polygenic risk scores.

Conclusion: This pilot study indicates that it is unlikely that DNA methylation and polygenic scores can predict suicidal ideation in schizophrenia.

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DNA甲基化和多基因评分对精神病患者自我报告的自杀意念的影响：无多基因风险的表观遗传基础证据。

精神分裂症是一个重要的临床问题。不幸的是，目前还没有生物标记物可以准确地识别可能容易自杀的精神分裂症患者。由于遗传和环境因素在自杀中起作用，我们试图确定DNA甲基化和多基因风险评分在自杀意念关系中的作用。方法：采用横断面研究设计，对98例精神分裂症谱系障碍患者进行访谈，采用贝克自杀意念量表评估自杀意念，并采集全血进行甲基化分析。结果：我们的分析显示cg21813303甲基化与自杀意念相关，但这种关联不具有全基因组意义。自杀的多基因风险评分与精神分裂症的严重程度无关，DNA甲基化与多基因风险评分之间没有生物学关系。结论：这项初步研究表明，DNA甲基化和多基因评分不太可能预测精神分裂症患者的自杀意念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.