Targeted delivery aspects of proanthocyanidins in breast cancer treatment: from discovery to development.

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Krishna Kuna, Seshadri Nalla, Jailani Shiekmydeen, Pavan C Akkiraju, Mahesh P More, Srinivas Ganta, Srinivas Enaganti, Rahul S Tade
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引用次数: 0

Abstract

Proanthocyanidins (PACs), a group of naturally occurring polyphenolic compounds found in a variety of fruits, vegetables, nuts, and seeds, have shown remarkable potential in the treatment of breast cancer (BC). These bioactive molecules exhibit antioxidant, anti-inflammatory, and anticancer properties by triggering apoptosis, halting cell cycle progression, and suppressing angiogenesis and metastasis. PACs further contribute to immune modulation and regulate critical signaling pathways like PI3K/Akt and MAPK, which are closely linked to cancer development. When combined with other bioactive agents, PACs have been shown to enhance therapeutic efficacy. Advanced delivery approaches, including PAC conjugation with targeting molecules and natural biopolymers, such as proteins and polysaccharides, are being explored to improve their effectiveness. Despite increasing interest in the anticancer potential of PACs, a comprehensive analysis of their molecular mechanisms, synergistic effects, and formulation strategies specifically in the context of breast cancer is lacking. This review aims to fill that gap by compiling and critically evaluating current preclinical evidence, novel delivery approaches, and safety considerations related to PACs in breast cancer therapy. Although preclinical investigations provide encouraging evidence, the availability of clinical studies remains scarce, emphasizing the need for further exploration. The discussion also encompasses the safety profile and possible toxicological concerns of PACs, underlining their therapeutic potential and existing challenges. Despite current limitations, PACs hold promise for BC treatment, with future research aiming to refine their clinical applicability.

原花青素在乳腺癌治疗中的靶向递送:从发现到发展。
原花青素(PACs)是一组天然存在的多酚类化合物,存在于各种水果、蔬菜、坚果和种子中,在治疗乳腺癌(BC)方面显示出显着的潜力。这些生物活性分子通过触发细胞凋亡、停止细胞周期进程、抑制血管生成和转移,表现出抗氧化、抗炎和抗癌特性。PACs进一步参与免疫调节,并调节与癌症发展密切相关的关键信号通路,如PI3K/Akt和MAPK。当与其他生物活性药物联合使用时,PACs已被证明可以提高治疗效果。先进的递送方法,包括PAC与靶向分子和天然生物聚合物(如蛋白质和多糖)的偶联,正在探索以提高其有效性。尽管人们对PACs的抗癌潜力越来越感兴趣,但缺乏对其分子机制、协同效应和配方策略的全面分析,特别是在乳腺癌的背景下。本综述旨在通过汇编和批判性评估目前的临床前证据、新的给药方法和与PACs在乳腺癌治疗中的安全性考虑来填补这一空白。尽管临床前调查提供了令人鼓舞的证据,但临床研究的可用性仍然很少,强调需要进一步探索。讨论还包括PACs的安全性和可能的毒理学问题,强调其治疗潜力和现有挑战。尽管目前存在局限性,但PACs有望用于BC治疗,未来的研究旨在完善其临床适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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