Association of positive airway pressure adherence with use of antihypertensive drugs in patients with sleep apnoea.

IF 4 3区医学 Q1 RESPIRATORY SYSTEM

ERJ Open Research Pub Date : 2025-08-04 eCollection Date: 2025-07-01 DOI:10.1183/23120541.00081-2025

Dany Jaffuel, Erika Nogue, François Roubille, Jean-Pierre Mallet, Sébastien Bailly, François Goupil, Audrey Thomas, Carole Hervé, Philippe Masson, Acya Bizieux-Thaminy, Margaux Blanchard, Sandrine Kerbrat, Abdelkebir Sabil, Wojciech Trzepizur, Camille Roubille, Sarah Skinner, Arnaud Bourdin, Nicolas Molinari, Frédéric Gagnadoux

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Abstract

Background: The impact of positive airway pressure (PAP) therapy on the use of oral antihypertensive drugs (OAHDs) in patients with obstructive sleep apnoea (OSA) remains unclear. This study aimed to evaluate the association between PAP use and the delivery of OAHDs.

Methods: Data from the Pays de la Loire Sleep Cohort were linked with the French health insurance database to quantify OAHD delivery in patients with hypertension at the initiation of PAP therapy. The primary end-point was the change in OAHD score, reflecting the number of OAHD classes delivered. PAP use groups were defined as: termination, 0-<4 h·day^-1, 4-<6 h·day^-1 and ≥6 h·day^-1.

Results: The study included 2205 OSA patients (median (Q1-Q3) apnoea-hypopnea index of 39 (30-55) events·h^-1), of whom 68% were male. The median age was 61 (54-68) years, the body mass index (BMI) was 32.42 (28.95-36.43) kg·m^-2 and the Epworth score was 10 (6-13). After 1 year of PAP, the mean±sd OAHD score decreased from 2.16±1.11 to 2.13±1.18 with no significant difference between PAP use groups. Respectively, 11.93% and 11.07% of patients experienced a decrease or increase in OAHD score, with no significant difference between PAP use groups. Multivariate analysis revealed that an increase in OAHD score was significantly positively associated with age, usage of calcium channel blockers and number of consultations. A decrease in OAHD score was significantly associated with baseline OAHD score, number of consultations, use of loop diuretics and a decrease in medication possession ratio.

Conclusion: PAP use is not associated with a change in OAHD score after 1 year.

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睡眠呼吸暂停患者气道正压依从性与抗高血压药物使用的关系。

背景：气道正压（PAP）治疗对阻塞性睡眠呼吸暂停（OSA）患者口服降压药（OAHDs）使用的影响尚不清楚。本研究旨在评估PAP使用与OAHDs分娩之间的关系。方法：来自卢瓦尔河睡眠队列的数据与法国健康保险数据库相关联，量化PAP治疗开始时高血压患者的OAHD分娩。主要终点是OAHD评分的变化，反映了交付的OAHD课程的数量。PAP使用组定义为：终止、0—1、4—1和≥6 h·day-1。结果：本研究纳入2205例OSA患者，中位（Q1-Q3）呼吸暂停低通气指数为39（30-55）次·h-1，其中68%为男性。年龄中位数61（54 ~ 68）岁，体重指数（BMI） 32.42 (28.95 ~ 36.43) kg·m-2， Epworth评分10（6 ~ 13）分。PAP治疗1年后，平均±sd OAHD评分由2.16±1.11降至2.13±1.18，两组间差异无统计学意义。分别有11.93%和11.07%的患者OAHD评分降低或升高，PAP使用组间差异无统计学意义。多因素分析显示，OAHD评分的增加与年龄、钙通道阻滞剂的使用和就诊次数显著正相关。OAHD评分的降低与基线OAHD评分、咨询次数、循环利尿剂的使用和药物持有率的降低显著相关。结论：PAP的使用与1年后OAHD评分的变化无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ERJ Open Research Medicine-Pulmonary and Respiratory Medicine

CiteScore

6.20

自引率

4.30%

发文量

273

审稿时长

8 weeks

期刊介绍： ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.