Hallmarks and mechanisms of cellular senescence in aging and disease.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-08-04 DOI:10.1038/s41420-025-02655-x

Amir Ajoolabady, Domenico Pratico, Suhad Bahijri, Basmah Eldakhakhny, Jaakko Tuomilehto, Feng Wu, Jun Ren

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Abstract

Cellular senescence, often referred to simply as "senescence", is a complex intracellular process with diverse biological, physiological, and pathological roles. Biologically, it is essential for embryogenesis and development. Physiologically, senescence acts as a safeguard against tumorigenesis by preventing the proliferation of damaged or defective cells. However, persistent activation of senescence can contribute to various pathological conditions, particularly those associated with aging, cancer, and other chronic diseases such as liver and pulmonary diseases. Growing evidence links aging to heightened activation of cellular senescence, leading to the accumulation of senescent cells. Here in this perspective, we aim to decipher the latest molecular mechanisms and regulatory pathways of cellular senescence in the context of aging and aging-related diseases. Additionally, we discuss emerging research directions, highlighting current limitations and gaps in the field. Addressing these challenges may not only advance our understanding of senescence but also uncover new therapeutic opportunities.

Abstract Image

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衰老和疾病中细胞衰老的特征和机制。

细胞衰老，通常简称为“衰老”，是一个复杂的细胞内过程，具有多种生物、生理和病理作用。在生物学上，它对胚胎发生和发育至关重要。生理上，衰老通过防止受损或有缺陷的细胞增殖来防止肿瘤发生。然而，持续的衰老激活会导致各种病理状况，特别是与衰老、癌症和其他慢性疾病（如肝脏和肺部疾病）相关的疾病。越来越多的证据表明，衰老与细胞衰老的激活加剧有关，从而导致衰老细胞的积累。从这个角度来看，我们的目标是在衰老和衰老相关疾病的背景下破译细胞衰老的最新分子机制和调控途径。此外，我们还讨论了新兴的研究方向，强调了该领域目前的局限性和差距。解决这些挑战不仅可以促进我们对衰老的理解，还可以发现新的治疗机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.