Landscape of interventional clinical trials for glenohumeral instability

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2025-07-15 DOI:10.1016/j.jor.2025.07.010

Mohamad Y. Fares , Matthew Como , Joseph A. Abboud , Albert Lin

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引用次数: 0

Abstract

Background

This study reviews interventional clinical trials to evaluate the efficacy and evolution of current therapeutic strategies for shoulder instability.

Methods

ClinicalTrials.gov was queried using key search terms for interventional clinical trials targeting shoulder instability. Data extracted included phase, status, duration, country, population size, age groups, study design, enrollment models, interventions, and outcomes. Publication rate was calculated by the ratio of published articles to total number of included trials.

Results

Forty-five interventional trials investigating shoulder instability were included. Most trials did not have a defined phase. Most trials (>90 %) began post-2010 with an average duration of 37 months. Europe/UK/Russia led in trial numbers (55.6 %). Primary endpoints focused on shoulder function and mobility, with the Western-Ontario-Shoulder-Instability-Index being the most common outcome measure. Interventions included surgical procedures (46.7 %), physical therapy (37.8 %), behavioral therapy (4.4 %), and other modalities (11.1 %). Nine trials produced 14 publications, resulting in a publication rate of 25.9 %. Published results varied, including comparisons of treatment efficacy, such as heavy versus light strengthening programs, and outcomes for surgical and non-surgical interventions.

Conclusion

Interventional trials on shoulder instability are limited, mostly originating from Europe and North America. Low publication rates and lack of blinding highlight areas for improvement. Publishing results is essential for continuous development and outcome improvement.

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肩关节不稳的介入临床试验概况

本研究回顾了介入临床试验，以评估当前治疗肩部不稳定策略的疗效和发展。方法使用针对肩部不稳定的介入临床试验的关键搜索词查询临床试验网站。提取的数据包括阶段、状态、持续时间、国家、人口规模、年龄组、研究设计、入组模型、干预措施和结果。发表率以发表文章数与纳入试验总数之比计算。结果纳入45项研究肩关节不稳的介入试验。大多数试验没有确定的阶段。大多数试验（90%）在2010年后开始，平均持续时间为37个月。欧洲/英国/俄罗斯在试验数量上领先（55.6%）。主要终点集中在肩关节功能和活动度上，其中最常见的指标是Western-Ontario-Shoulder-Instability-Index。干预措施包括外科手术（46.7%）、物理治疗（37.8%）、行为治疗（4.4%）和其他方式（11.1%）。9项试验发表了14篇论文，发表率为25.9%。发表的结果各不相同，包括治疗效果的比较，如重度与轻度强化计划，以及手术和非手术干预的结果。结论介入治疗肩关节不稳的临床试验有限，主要来自欧洲和北美。发表率低和缺乏盲目性突出了需要改进的地方。发布结果对于持续开发和结果改进至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.