High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer's Disease Study.

NPJ dementia Pub Date : 2025-01-01 Epub Date: 2025-07-30 DOI:10.1038/s44400-025-00015-1

Yara Alkhodair, Ging-Yuek R Hsiung, Boon Lead Tee, Pei-Chuan Ho, Phoenix Au Yeung, Wai Haung Yu, Guerry Peavy, Victor W Henderson, Yun-Beom Choi, Clara Li, Dolly Reyes-Dumeyer, Haeok Lee, Walter A Kukull

{"title":"High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer's Disease Study.","authors":"Yara Alkhodair, Ging-Yuek R Hsiung, Boon Lead Tee, Pei-Chuan Ho, Phoenix Au Yeung, Wai Haung Yu, Guerry Peavy, Victor W Henderson, Yun-Beom Choi, Clara Li, Dolly Reyes-Dumeyer, Haeok Lee, Walter A Kukull","doi":"10.1038/s44400-025-00015-1","DOIUrl":null,"url":null,"abstract":"<p><p>The Asian Cohort for Alzheimer's Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset's efficacy. Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen's Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen's Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.</p>","PeriodicalId":520469,"journal":{"name":"NPJ dementia","volume":"1 1","pages":"18"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310511/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ dementia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44400-025-00015-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/30 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

The Asian Cohort for Alzheimer's Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset's efficacy. Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen's Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen's Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.

Abstract Image

查看原文本刊更多论文

阿尔茨海默病亚洲队列研究中共识诊断和总体评估的高可靠性

亚洲阿尔茨海默病队列（ACAD）研究是一项针对亚裔美国人和加拿大人阿尔茨海默病遗传和非遗传风险因素的合作调查。跨招聘地点的诊断程序的协调将是数据集有效性的关键。在七个ACAD招募地点完成共识过程的42名参与者由另外两名公正的评分员重新审查。采用Cohen’s Kappa系数评价评分者之间的一致性。结果显示，在现场共识参与者和两个级别的外部审查中，观察到的一致性最高水平为88%，Cohen's Kappa为0.835，肯定了我们协议的可靠性。ACAD开发了一种数据收集和诊断流程，使服务讲韩语、汉语和越南语的亚洲人的网站保持一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

NPJ dementia

自引率

0.00%

发文量