The normalizing properties of intracranial volume across race and sex.

IF 4.5 Q1 CLINICAL NEUROLOGY

Brain communications Pub Date : 2025-07-16 eCollection Date: 2025-01-01 DOI:10.1093/braincomms/fcaf271

Peirong Liu, Dina Zemlyanker, Karthik Gopinath, You Cheng, Yingnan He, David Izquierdo-Garcia, Teresa Gomez-Isla, Sudeshna Das, Shahin Nasr, Kevin N Sheth, Matthew S Rosen, W Taylor Kimberly, Adam de Havenon, Francis X Shen, Juan Eugenio Iglesias

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引用次数: 0

Abstract

In volumetric analysis of the human brain with MRI, intracranial volume is an important covariate as it has a strong correlation with the volume of regions of interest in the brain. Therefore, accurate adjustment for intracranial volume (e.g. by division) is essential to mitigate the impact of head size on brain measurements. In this study, we assess the effects of intracranial volume normalization on differences across sex and racial groups, using a diverse cohort with 5977 subjects from three different (self-reported) races. We show that (i) differences in intracranial volume across sex are consistent across race and vice versa; and (ii) intracranial volume normalization almost completely accounts for differences by race and sex. These results suggest that subjects of different sexes and races can be safely aggregated in volumetric studies by normalizing the volume of regions of interest to intracranial volume.

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颅内容积在种族和性别上的正常化特性。

在用MRI对人脑进行体积分析时，颅内体积是一个重要的协变量，因为它与大脑中感兴趣区域的体积有很强的相关性。因此，精确调整颅内容量（例如通过分割）对于减轻头部尺寸对脑部测量的影响至关重要。在这项研究中，我们评估了颅内容积归一化对性别和种族差异的影响，使用了来自三个不同种族（自我报告）的5977名受试者的多样化队列。我们发现(i)颅内容积的性别差异在种族中是一致的，反之亦然；颅内容积归一化几乎完全解释了种族和性别的差异。这些结果表明，通过将感兴趣区域的体积归一化到颅内容积，可以安全地将不同性别和种族的受试者聚集在容量研究中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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