A strain-programmed lignin-based Janus patch for rapid healing of postoperative rectal wounds.

Abstract

Rationale: Clinically, patients experience severe pain, frequent bleeding, and delayed wound healing after hemorrhoidectomy due to recurrent fecal contamination during postoperative dressing changes and bowel movements, which exacerbate wound irritation. Methods: In this study, we developed a strain-programmed lignin-based multifunctional Janus patch (S-SFR@AGL) to accelerate rectal wound repair. This patch features a pre-stretched fluorinated silicone rubber side with robust anti-biofouling and strain-programmed properties, paired with a lignin-based hydrogel side offering potent antibacterial, antioxidant, bioadhesive, and hemostatic capabilities. Results: By modulating the wound's mechanical microenvironment and combating infection-induced inflammation, the patch healed infected rat rectal wounds within one week via effective bacterial clearance, attenuated inflammatory responses, and promoted muscle contraction and epithelial cell differentiation. Conclusions: This Janus patch could shorten intestinal wound healing time, potentially optimizing postoperative management after intestinal lesion resection.