Macrophages say NO to nucleotide synthesis and salvage instead

IF 20.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-08-04 DOI:10.1038/s42255-025-01322-w

Eloïse Marques, Dylan G. Ryan

引用次数: 0

Abstract

Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a previously unappreciated, system-wide remodelling of nucleotide metabolism driven by nitric oxide (NO), with important implications for inflammatory macrophage function and host–pathogen interactions.

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巨噬细胞对核苷酸合成和打捞产生NO反应

代谢重编程是巨噬细胞激活的一个公认的标志，协调生物能量和生物合成途径来支持免疫效应功能。一项新的研究揭示了由一氧化氮（NO）驱动的核苷酸代谢的以前未被认识的全系统重构，对炎症性巨噬细胞功能和宿主-病原体相互作用具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.