New weapons for the management of perianal Crohn's disease

Abstract

Perianal fistulas are a common complication of Crohn's disease (CD), affecting approximately 40 % of patients. Fistulas develop because of sustained transmural inflammation of the bowel wall. Despite advances in treatment, one-third of patients with CD continue to experience recurrent fistulas, and perianal CD remains a challenging condition. This review aims to explore emerging therapeutic strategies for perianal fistulizing CD, focusing on novel biologics, advances in surgical strategies, and combination therapies.