Assessment of the Effects of Cigarette Smoke on the Renal Morphology of WISTAR Rats.

IF 2.8 4区医学 Q3 TOXICOLOGY

Journal of Applied Toxicology Pub Date : 2025-08-02 DOI:10.1002/jat.4872

Cristiane Gomes Fernandes Freire, Luana Aparecida Cunha, Mateus Andrade Stecca, Isabele Masson de Brito, Rafaella Riccio da Silva, Thiago Donizeth da Silva, Margarida Pereira Santos, Márcia Cristina Bizinotto de Assunção, Geraldo José Medeiros Fernandes, Evelise Aline Soares

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引用次数: 0

Abstract

Smoking is a major public health concern worldwide. The toxic components of cigarettes, such as nicotine, can cause abuse, dependence, and tissue damage. This study aimed to evaluate the effects of exposure to cigarette smoke on the renal morphology of Wistar rats. For this purpose, 12 male rats were used, divided into two groups (n = 6): CT Group (control) and CG Group (cigarette). The CG Group was exposed to smoke from six cigarettes per day. After 12 weeks, the rats were euthanized, and the kidneys were collected, weighed, and processed histologically for renal tissue analysis. Although the increase in renal weight was not statistically significant (p = 0.479), the CG Group exhibited significantly reduced values for glomerular diameter, capsular area (p < 0.0001), subcapsular area (p = 0.0045), and glomerular tuft area (p = 0.0049) compared to the CT Group. These results indicate that cigarette smoke exposure induces morphological changes in renal structure, even in the absence of significant weight alteration.

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香烟烟雾对WISTAR大鼠肾脏形态影响的评价。

吸烟是世界范围内一个主要的公共卫生问题。香烟中的有毒成分，如尼古丁，会导致滥用、依赖和组织损伤。本研究旨在评价吸烟对Wistar大鼠肾脏形态的影响。为此，选用雄性大鼠12只，分为两组（n = 6）： CT组（对照组）和CG组（香烟组）。CG组每天接触六支香烟的烟雾。12周后，对大鼠实施安乐死，收集肾脏，称重，并进行组织学处理，进行肾组织分析。虽然肾脏重量的增加没有统计学意义（p = 0.479），但CG组肾小球直径、被囊面积显著降低（p = 0.479）

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来源期刊

Journal of Applied Toxicology 医学-毒理学

CiteScore

7.00

自引率

6.10%

发文量

145

审稿时长

1 months

期刊介绍： Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.