Innovations in Dental Implants Integration: Optimizing dental implants performance utilizing stem cells and coatings.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology Progress Pub Date : 2025-08-01 DOI:10.1002/btpr.70060

Ioannis Tsamesidis, Athanasios Christodoulou, Evangelia Stalika, Georgia K Pouroutzidou, Eleana Kontonasaki

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引用次数: 0

Abstract

The last two decades, between 2000 and 2024, significant steps were achieved regarding the interaction between various stem cells and titanium implant surfaces to improve dental implant integration. This literature review focuses on the potential effects of (i) bone marrow mesenchymal stem cells (BMSCs), (ii) periodontal ligament stem cells (PDLSCs), and (iii) dental follicle stem cells (DFSCs) in promoting osseointegration and tissue regeneration. Studies have shown that combining these stem cells with Ti implants enhances bone formation, accelerates implant osseointegration, and improves long-term implant stability. Additionally, animal models and bioreactors have been employed to evaluate the effects of stem cells on dental implant performance, with some studies showing promising results, although certain models have also yielded inconsistent outcomes. The interaction between stem cells and surface-modified Ti implants has emerged as a key area of research, with results indicating improved healing times and reduced failure rates. This article provides an overview of these findings, highlighting the role of stem cells in not only replacing lost teeth but also actively regenerating the surrounding biological structures for a more integrated and natural outcome.

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牙种植体整合创新：利用干细胞和涂层优化牙种植体性能。

在过去的二十年中，从2000年到2024年，在各种干细胞与钛种植体表面的相互作用方面取得了重大进展，以改善牙科种植体的整合。本文综述了骨髓间充质干细胞（BMSCs）、牙周韧带干细胞（PDLSCs）和牙毛囊干细胞（DFSCs）在促进骨整合和组织再生方面的潜在作用。研究表明，将这些干细胞与钛种植体结合可促进骨形成，加速种植体骨整合，提高种植体的长期稳定性。此外，动物模型和生物反应器已被用于评估干细胞对牙种植体性能的影响，一些研究显示出有希望的结果，尽管某些模型也产生了不一致的结果。干细胞与表面修饰钛植入物之间的相互作用已成为研究的关键领域，其结果表明可以缩短愈合时间并降低故障率。这篇文章提供了这些发现的概述，强调干细胞的作用不仅是替换失去的牙齿，而且还积极地再生周围的生物结构，以获得更完整和自然的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology Progress 工程技术-生物工程与应用微生物

CiteScore

6.50

自引率

3.40%

发文量

审稿时长

4 months

期刊介绍： Biotechnology Progress , an official, bimonthly publication of the American Institute of Chemical Engineers and its technological community, the Society for Biological Engineering, features peer-reviewed research articles, reviews, and descriptions of emerging techniques for the development and design of new processes, products, and devices for the biotechnology, biopharmaceutical and bioprocess industries. Widespread interest includes application of biological and engineering principles in fields such as applied cellular physiology and metabolic engineering, biocatalysis and bioreactor design, bioseparations and downstream processing, cell culture and tissue engineering, biosensors and process control, bioinformatics and systems biology, biomaterials and artificial organs, stem cell biology and genetics, and plant biology and food science. Manuscripts concerning the design of related processes, products, or devices are also encouraged. Four types of manuscripts are printed in the Journal: Research Papers, Topical or Review Papers, Letters to the Editor, and R & D Notes.